Acute and long-term cognitive impairment following sepsis: mechanism and prevention

Ji, Mu-Huo; Gao, Yu-Zhu; Shi, Cui-Na; Wu, Xin-Miao; Yang, Jian-Jun

doi:10.1080/14737175.2023.2250917

Cited by 4 publications

(1 citation statement)

References 199 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sepsis is a syndrome characterized by multiple organ dysfunction and a systemic inflammatory response caused by an infection that induces acute and long-term cognitive impairment [ 1 ]. Despite recent advances in anti-infection therapy and organ function support technology, the mortality rate from sepsis remains as high as 30–60% [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Mangiferin attenuates lipopolysaccharide-induced neuronal injuries in primary cultured hippocampal neurons

Tan,

Liang,

et al. 2024

Aging

View full text Add to dashboard Cite

Mangiferin, a naturally occurring potent glucosylxanthone, is mainly isolated from the Mangifera indica plant and shows potential pharmacological properties, including anti-bacterial, anti-inflammation, and antioxidant in sepsis-induced lung and kidney injury. However, there was a puzzle as to whether mangiferin had a protective effect on sepsis-associated encephalopathy. To answer this question, we established an in vitro cell model of sepsis-associated encephalopathy and investigated the neuroprotective effects of mangiferin in primary cultured hippocampal neurons challenged with lipopolysaccharide (LPS). Neurons treated with 20 μmol/L or 40 μmol/L mangiferin for 48 h can significantly reverse cell injuries induced by LPS treatment, including improved cell viability, decreased inflammatory cytokines secretion, relief of microtubule-associated light chain 3 expression levels and several autophagosomes, as well as attenuated cell apoptosis. Furthermore, mangiferin eliminated pathogenic proteins and elevated neuroprotective factors at both the mRNA and protein levels, showing strong neuroprotective effects of mangiferin, including anti-inflammatory, anti-autophagy, and anti-apoptotic effects on neurons in vitro .

show abstract

Section: Introductionmentioning

confidence: 99%

Mangiferin attenuates lipopolysaccharide-induced neuronal injuries in primary cultured hippocampal neurons

Tan,

Liang,

et al. 2024

Aging

View full text Add to dashboard Cite

show abstract

Recovery from Sepsis: Management beyond Acute Care

Andersen,

Herridge,

Fiest

2024

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Recovery from sepsis is a key global health issue, impacting 38 million sepsis survivors worldwide per year. Sepsis survivors face a wide range of physical, cognitive, and psychosocial sequelae. Readmissions to hospital following sepsis are an important driver of global healthcare utilization and cost. Family members of sepsis survivors also experience significant stressors related to their role as informal caregivers. Increasing recognition of the burdens of sepsis survivorship has led to the development of postsepsis recovery programs to better support survivors and their families, although optimal models of care remain uncertain. The goal of this article is to perform a narrative review of recovery from sepsis from the perspective of patients, families, and health systems.

show abstract

Treatment of septic encephalopathy and encephalitis – a critical appraisal

Tauber,

Nau

2023

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

Acute and long-term cognitive impairment following sepsis: mechanism and prevention

Cited by 4 publications

References 199 publications

Mangiferin attenuates lipopolysaccharide-induced neuronal injuries in primary cultured hippocampal neurons

Mangiferin attenuates lipopolysaccharide-induced neuronal injuries in primary cultured hippocampal neurons

Recovery from Sepsis: Management beyond Acute Care

Treatment of septic encephalopathy and encephalitis – a critical appraisal

Contact Info

Product

Resources

About