Acute and chronic methylphenidate administration in intact and VTA-specific and nonspecific lesioned rats

Ihezie, Stephanie A; Thomas, Ming; Dafny, Nachum

doi:10.1007/s00702-018-1963-4

Cited by 6 publications

(3 citation statements)

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“…Immune destruction followed by immune reconstitution and then exposing the animals to chronic morphine, and 72 hours later treating with naloxone, these animals expressed all of the seven behavioral withdrawal symptoms. The role and contribution of brain structures or organ systems to a particular behavioral or physiological phenomenon are often studied in animal models where the organ or a specific structure was ablated [11,19,[21][22][23][24]. In these studies, the animals were Figure 1A:Summarizes five experimental groups, each N=8.…”

Section: Discussionmentioning

confidence: 99%

Evidence that the Immune System Participates in the Expression of Opiate Withdrawal Behavior

Dafny¹

2020

J Addict Sci

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The objective of this manuscript is to summarize studies that demonstrate that the immune system participates in the expression of opiate withdrawal. Five groups of animals were used: 1. Chronic morphine control group; 2. The immune system was ablated in morphine-dependent rats; 3. In morphine-dependent animals the immune system was ablated and followed by reconstitution of the immune system from intact normal donor animals; 4.The immune system was ablated prior to chronic morphine exposure; and, 5. The immune system in morphine-naïve animals was ablated followed by immune component reconstitution from donor animals and then exposed to chronic morphine. All of the chronic morphine exposure animals were injected with 1.0 mg/kg naloxone to precipitate the behavioral withdrawal symptoms. In the first group, naloxone precipitated the classical behavioral syndrome; in groups 2 and 4 withdrawal symptoms were significantly attenuated and eliminated in some animals; and, in groups 3 and 5 naloxone injection resulted in severe withdrawal behavior. These experiments demonstrated that the immune system participates in opiate withdrawal expression and suggest the use of immunotherapy to control the opioid epidemic.

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Section: Discussionmentioning

confidence: 99%

Evidence that the Immune System Participates in the Expression of Opiate Withdrawal Behavior

Dafny¹

2020

J Addict Sci

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“…The methods used in this review were published in detail [4,7,11,[13][14][15]59,60,68,69]. In short, 160 male Sprague-Dawley rats weighing 170-180 g were obtained from Harlan Labs (Indianapolis, IN, USA).…”

Section: Methodsmentioning

confidence: 99%

The Ventral Tegmental Area (VTA), the Nucleus Accumbens (NAc), the Caudate Nucleus (CN) and the Prefrontal Cortex (PFC) role in the Response to Acute and Chronic Methylphenidate

King

Dafny

2023

Journal of Experimental Neurology

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Methylphenidate (MPD) is psychostimulant, similar to cocaine and amphetamine, that is commonly used to treat attention deficit hyperactivity disorder and is increasingly being abused by healthy subjects for its psychoactive effects such as memory retention cognitive enhancement for young, adult and the elderly and recreation. MPD’s action on the brain reward/motive circuit is still under investigation, however it is known that in animals chronic use of MPD leads to behavioral sensitization, an experimental indicator associated with dependence. To investigate this neural circuit’s role in response to acute and chronic MPD, three different lesions (non-specific, dopaminergic specific, and glutaminergic specific lesions) have been conducted at the nucleus accumbens (NAc), the ventral tegmental area (VTA), the caudate nucleus (CN), and the prefrontal cortex (PFC), to assess the structure, dopaminergic signaling, and glutaminergic signaling roles in response to MPD. The three types of lesions show that each one of the above four brain areas participate differently in the acute and chronic effect of MPD and have helped determine which type of signaling is critical for the acute and/or chronic behavioral adaptions to MPD.

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“…Methylphenidate (MPH) is one of most commonly prescribed ADHD medications and is highly efficacious in treating ADHD symptoms (Pliszka et al, 2017). MPH prevents the reuptake of norepinephrine and dopamine within their respective neuroregulation systems (Hannestad et al, 2010;Ihezie et al, 2019)…”

Section: Methylphenidatementioning

confidence: 99%

Emotional and sensory dysregulation as a possible missing link in attention deficit hyperactivity disorder: A review

Grossman

Avital²

2023

Front. Behav. Neurosci.

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Attention Deficit Hyperactivity Disorder (ADHD) is a common developmental disorder affecting 5-7% of adults and children. We surveyed the literature to examine ADHD through three pillars: developmental characteristics, symptomatology, and treatment strategies. Firstly, in terms of developmental characterstics, early life stress may increase the risk of developing ADHD symptoms according to animal models’ research. Secondly, the current core symptoms of ADHD are comprised of inattention, hyperactivity, and impulsivity. However, the up-to-date literature indicates individuals with ADHD experience emotional and sensory dysregulation as well, which early-life stress may also increase the risk of. Finally, we discuss the therapeutic benefits of methylphenidate on both the current core ADHD symptoms and the sensory and emotional dysregulation found in those with ADHD. In summation, we surveyed the recent literature to analyze (i) the potential role of early-life stress in ADHD development, (ii) the involvement of emotional and sensory dysregulation in ADHD symptomatology and finally, (iii) the therapeutic intervention with methylphenidate, aiming to reduce the potential effect of early life stress in ADHD, and mainly emotional and sensory dysregulation. The apparent but currently less recognized additional symptoms of emotional and sensory dysregulation in ADHD call for further investigation of these possible causes and thus increasing treatments efficacy in individuals with ADHD.

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Acute and chronic methylphenidate administration in intact and VTA-specific and nonspecific lesioned rats

Cited by 6 publications

References 74 publications

Evidence that the Immune System Participates in the Expression of Opiate Withdrawal Behavior

Evidence that the Immune System Participates in the Expression of Opiate Withdrawal Behavior

The Ventral Tegmental Area (VTA), the Nucleus Accumbens (NAc), the Caudate Nucleus (CN) and the Prefrontal Cortex (PFC) role in the Response to Acute and Chronic Methylphenidate

Emotional and sensory dysregulation as a possible missing link in attention deficit hyperactivity disorder: A review

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