Acute and chronic effects of Titanium dioxide (TiO2) PM1 on honey bee gut microbiota under laboratory conditions

Papa, Giulia; Prisco, Gennaro Di; Spini, Giulia; Puglisi, Edoardo; Negri, Ilaria

doi:10.1038/s41598-021-85153-1

Cited by 16 publications

(13 citation statements)

References 72 publications

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“…For instance, nitrates/nitrites 24 – 26 , carrageenans 31 , glutamate 32 – 34 , bixin 35 , 36 , artificial sweeteners 21 , 37 – 40 , phosphates 41 , 42 , emulsifiers 43 – 46 , caramel 47 , tartrazine 48 , 49 and butylated hydroxyanisole/ butylated hydroxytoluene (BHA/BHT) 48 were previously linked to metabolic, gut microbiota or endocrine perturbations along with carcinogenic, inflammatory and/or oxidative stress effects. Also, in May 2021, following an updated evaluation, EFSA reviewed its position on titanium dioxide (TiO 2 ) and stated that this additive could no longer be considered as safe 22 , 50 – 52 . Besides, some experimental results suggest potential interactions between some food additives and/or with the food matrix leading to synergistic or antagonist effects on health 4, yet profiles of exposure to additive mixtures in humans are poorly documented.…”

Section: Introductionmentioning

confidence: 99%

Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort

Chazelas

Druesne-Pecollo

Esseddik

et al. 2021

Sci Rep

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Food additives (e.g. artificial sweeteners, emulsifiers, dyes, etc.) are ingested by billions of individuals daily. Some concerning results, mainly derived from animal and/or cell-based experimental studies, have recently emerged suggesting potential detrimental effects of several widely consumed additives. Profiles of additive exposure as well as the potential long-term impact of multiple exposure on human health are poorly documented. This work aimed to estimate the usual intake of food additives among participants of the French NutriNet-Santé cohort and to identify and describe profiles of exposure (single substances and mixtures). Overall, 106,489 adults from the French NutriNet-Santé cohort study (2009-ongoing) were included. Consumption of 90 main food additives was evaluated using repeated 24 h dietary records including information on brands of commercial products. Qualitative information (as presence/absence) of each additive in food products was determined using 3 large-scale composition databases (OQALI, Open Food Facts, GNPD), accounting for the date of consumption of the product. Quantitative ingested doses were estimated using a combination of laboratory assays on food matrixes (n = 2677) and data from EFSA and JECFA. Exposure was estimated in mg per kg of body weight per day. Profiles of exposure to food additive mixtures were extracted using Non-negative Matrix Factorization (NMF) followed by k-means clustering as well as Graphical Lasso. Sociodemographic and dietary comparison of clusters of participants was performed by Chi-square tests or linear regressions. Data were weighted according to the national census. Forty-eight additives were consumed by more than 10% of the participants, with modified starches and citric acid consumed by more than 90%. The top 50 also included several food additives for which potential adverse health effects have been suggested by recent experimental studies: lecithins (86.6% consumers), mono- and diglycerides of fatty acids (78.1%), carrageenan (77.5%), sodium nitrite (73.9%), di-, tri- and polyphosphates (70.1%), potassium sorbate (65.8%), potassium metabisulphite (44.8%), acesulfame K (34.0%), cochineal (33.9%), potassium nitrate (31.6%), sulfite ammonia caramel (28.8%), bixin (19.5%), monosodium glutamate (15.1%) and sucralose (13.5%). We identified and described five clusters of participants more specifically exposed to five distinct additive mixtures and one additional cluster gathering participants with overall low additive exposure. Food additives, including several for which health concerns are currently debated, were widely consumed in this population-based study. Furthermore, main mixtures of additives were identified. Their health impact and potential cocktail effects should be explored in future epidemiological and experimental studies.

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Section: Introductionmentioning

confidence: 99%

Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort

Chazelas

Druesne-Pecollo

Esseddik

et al. 2021

Sci Rep

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“…Current studies on the oral exposure of pollinators to particles indicate both lethal and sub-lethal effects [ 101 , 102 ]. In particular, cytological and histological modifications of the gut epithelium or alterations in the gut microbial community have been demonstrated [ 103 , 104 , 105 ]. Indeed, ingested particles can come into contact with epithelial cells and the microbiome lining the gut, posing hazards to the gut community [ 105 ].…”

Section: Airborne Particulate Matter (Pm) and Characteristics And Eff...mentioning

confidence: 99%

Rethinking the Connections between Ecosystem Services, Pollinators, Pollution, and Health: Focus on Air Pollution and Its Impacts

Plutino

Bianchetto²,

Durazzo³

et al. 2022

IJERPH

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Ecosystems provide many services that are essential for human activities and for our well-being. Many regulation services are interconnected and are fundamental in mitigating and hindering the negative effects of several phenomena such as pollution. Pollution, in particular airborne particulate matter (PM), represents an important risk to human health. This perspective aims at providing a current framework that relates ecosystem services, regulating services, pollination, and human health, with particular regards to pollution and its impacts. A quantitative literature analysis on the topic has been adopted. The health repercussions of problems related to ecosystem services, with a focus on the effects of atmospheric particulate matter, have been highlighted in the work throughout a case study. In polluted environments, pollinators are severely exposed to airborne PM, which adheres to the insect body hairs and can be ingested through contaminated food resources, i.e., pollen and honey. This poses a serious risk for the health of pollinators with consequences on the pollination service and, ultimately, for human health.

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Section: Nutritional Value Bioactive Components and Beneficial Properties Of Bee Productsmentioning

confidence: 99%

“…The most recent work was published by Papa et al [ 216 ] and studied the acute and chronic effects of titanium dioxide (TiO 2 ) particulate matter on honeybee gut microbiota under laboratory conditions. Acute and chronic oral administration of ultrapure TiO 2 particulate matter to adult bees altered the bee microbial community; therefore, airborne particulate matter may represent an additional risk factor for honeybee health, promoting sublethal effects against the gut microbiota [ 216 ]. The second most recent paper was a work by Sharif et al [ 217 ] that, by looking for new, non-invasive methods to monitor the health status of the colony, introduced new features for classifying beehive audio samples using the soundscape indices [ 217 ].…”

Section: Nutritional Value Bioactive Components and Beneficial Properties Of Bee Productsmentioning

confidence: 99%

Bee Products: A Representation of Biodiversity, Sustainability, and Health

Durazzo¹,

Lucarini²,

Plutino

et al. 2021

Life

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Biodiversity strengthens the productivity of any ecosystem (agricultural land, forest, lake, etc.). The loss of biodiversity contributes to food and energy insecurity; increases vulnerability to natural disasters, such as floods or tropical storms; and decreases the quality of both life and health. Wild and managed bees play a key role in maintaining the biodiversity and in the recovery and restoration of degraded habitats. The novelty character of this perspective is to give an updated representation of bee products’ biodiversity, sustainability, and health relationship. The role of bees as bioindicators, their importance in the conservation of biodiversity, their ecosystem services, and the variety of the bee products are described herein. An overview of the main components of bee products, their biological potentials, and health is highlighted and detailed as follows: (i) nutritional value of bee products, (ii) bioactive profile of bee products and the related beneficial properties; (iii) focus on honey and health through a literature quantitative analysis, and (iv) bee products explored through databases. Moreover, as an example of the interconnection between health, biodiversity, and sustainability, a case study, namely the “Cellulose Park”, realized in Rome (Italy), is presented here. This case study highlights how bee activities can be used to assess and track changes in the quality of agricultural ecosystems—hive products could be valid indicators of the quality and health of the surrounding environment, as well as the changes induced by the biotic and abiotic factors that impact the sustainability of agricultural production and biodiversity conservation in peri-urban areas.

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Acute and chronic effects of Titanium dioxide (TiO2) PM1 on honey bee gut microbiota under laboratory conditions

Cited by 16 publications

References 72 publications

Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort

Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort

Rethinking the Connections between Ecosystem Services, Pollinators, Pollution, and Health: Focus on Air Pollution and Its Impacts

Bee Products: A Representation of Biodiversity, Sustainability, and Health

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