J. Neurosci. Res. volume 85, issue 11, P2491-2499 2007 DOI: 10.1002/jnr.21385 View full text
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Elena Kosenko, Yuri Kaminsky, Ilia Solomadin, Nikolay Marov, Natalia Venediktova, Vicente Felipo, Carmina Montoliu

Abstract: Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo leads to induction of apoptotic markers such as permeability transition pore (PTP) formation, caspase-3, and caspase-9 activation, changes in p53 protein, or cytochrome c release. Acute ammonia into…

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