Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato- and nephrotoxic effects in Wistar rats

Robot‐assisted partial nephrectomy is associated with early recovery of renal function: Comparison of open, laparoscopic, and robot‐assisted partial nephrectomy using DTPA renal scintigraphy

“…Flank or abdominal incisions in OPN require more analgesia for postoperative pain control . Analgesics could decrease systemic arterial blood pressure and therefore increase antidiuretic hormone and central sympathetic outflow, which act to decrease renal perfusion . In the early period after surgery, compensatory mechanisms of the remnant kidney might be insufficient .…”

“…18 Analgesics could decrease systemic arterial blood pressure and therefore increase antidiuretic hormone and central sympathetic outflow, which act to decrease renal perfusion. 19 In the early period after surgery, compensatory mechanisms of the remnant kidney might be insufficient. 20 At such a time, accumulation of analgesics failed to demonstrate the effectiveness of sunitinib or sorafenib, 26 but the sunitinib treatment of renal adjuvant cancer (S-TRAC) trial showed a significant benefit in disease-free survival.…”

Comparative pharmacology and toxicology of tramadol and tapentadol

“…Several studies with animal models documented tramadol‐induced toxicity in different organs, such as liver, kidney, brain, heart and lung (Atici et al., ; Samaka et al., ; Ezzeldin et al., ; Ghoneim et al., ; Saleem et al., ; Awadalla and Salah‐Eldin, ; Barbosa et al., ; Faria et al., ). Tramadol toxicity was observed through biochemical and histological analyses.…”

“…Tramadol toxicity was observed through biochemical and histological analyses. Several alterations were detected, such as increased aminotransferase activity, creatinine and blood urea nitrogen (BUN) (Atici et al., ; Saleem et al., ; Barbosa et al., ; Faria et al., ); increased oxidative stress markers (e.g. malondialdehyde levels and decreased antioxidant activity) (Ghoneim et al., ; Awadalla and Salah‐Eldin, ; Barbosa et al., ; Faria et al., ) and histopathological alterations (e.g.…”

“…Several alterations were detected, such as increased aminotransferase activity, creatinine and blood urea nitrogen (BUN) (Atici et al., ; Saleem et al., ; Barbosa et al., ; Faria et al., ); increased oxidative stress markers (e.g. malondialdehyde levels and decreased antioxidant activity) (Ghoneim et al., ; Awadalla and Salah‐Eldin, ; Barbosa et al., ; Faria et al., ) and histopathological alterations (e.g. necrosis, vacuolization, mononuclear cell infiltration) (Atici et al., ; Samaka et al., ; El Fatoh et al., ; Ezzeldin et al., ; Ghoneim et al., ; Saleem et al., ; Awadalla and Salah‐Eldin, ; Barbosa et al., ; Faria et al., ).…”