Acupuncture for polycystic ovarian syndrome

Jo, Junyoung; Lee, Yoon Jae; Lee, Hyangsook

doi:10.1097/md.0000000000007066

Cited by 38 publications

(10 citation statements)

References 39 publications

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“…Zhou et al [ 28 ] found that acupuncture improves the hot flashes in bilaterally ovariectomized women which has relationship with modulated FSH and E2 level. In addition, there are 2 metareviews showing that acupuncture is beneficial for polycystic ovarian syndrome that has association with modulated LH, LH/FSH, and testosterone [ 29 , 30 ]. Despite this, whether the acupuncture beneficial for perimenopause with depression is associated with sexual hormones remained unclear.…”

Section: Discussionmentioning

confidence: 99%

A Multicenter, Randomized, Controlled Trial of Electroacupuncture for Perimenopause Women with Mild-Moderate Depression

et al. 2018

BioMed Research International

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Objective Up to 62% of perimenopausal women have depression symptoms. However, there is no efficacy treatment. The aim of this study is to compare the clinical efficacy and safety of EA therapy and escitalopram on perimenopause women with mild-moderate depressive symptom. Method A multicenter, randomized, positive-controlled clinical trial was conducted at 6 hospitals in China. 242 perimenopause women with mild-moderate depressive symptom were recruited and randomly assigned to receive 36 sessions of EA treatment or escitalopram treatment. The primary outcome measure was the 17-item Hamilton Depression Rating Scale (HAMD-17). The secondary outcome measures include menopause-specific quality of life (MENQOL) and serum sexual hormones which include estrogen, follicle-stimulating hormone, and luteinizing hormone. Results 221 (91.3%) completed the study, including 116 in the EA group and 105 in the escitalopram group. The baseline levels of demographic and outcome measurements were similar in the two groups. In the intervention period, there was no difference between two groups. However, in the follow-up, both HAMD-17 and MENQOL were significantly decreased, and at week 24 the mean differences were −2.23 and −8.97, respectively. There were no significant differences in the change of serum sexual hormones between the two groups. No serious adverse events occurred. Conclusion EA treatment is effective and safe in relieving depression symptom and improving the quality of life in the perimenopausal depression. Further research is needed to understand long-term efficacy and explore the mechanism of this intervention. This study is registered with ClinicalTrials.gov NCT02423694.

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Section: Discussionmentioning

confidence: 99%

A Multicenter, Randomized, Controlled Trial of Electroacupuncture for Perimenopause Women with Mild-Moderate Depression

et al. 2018

BioMed Research International

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“…According to a systematic review, no studies have reported the comparison of acupuncture to sham-acupuncture in terms of menstruation frequency at present. [ 35 ] In order to reduce the placebo effect of sham-acupuncture, the expectation value of the acupuncture effect will be evaluated before treatment.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of acupuncture on menstrual frequency in women with polycystic ovary syndrome

Zhou

Yang

et al. 2017

Medicine

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Background:Acupuncture may improve the menstrual frequency of women with polycystic ovary syndrome (PCOS). However, more sufficient data are needed to improve the efficacy of acupuncture.Methods:A total of 172 participants diagnosed with PCOS would be randomly assigned to either the acupuncture group or sham-acupuncture group, at a ratio of 1:1. Participants in both groups will receive treatment for 12 weeks, 3 times a week. The primary outcome will be the proportion of participants with at least a 50% increase from baseline in the monthly menstrual frequency from baseline after 12 weeks intervention, while secondary outcomes will be the difference in anthropometrics, serum hormone level, ovarian morphology, anxiety and depression, and quality of life from baseline to after 12 weeks intervention and to 12 weeks postintervention follow-up between groups.Discussion:The aim of this study is to evaluate the efficacy and safety of acupuncture for improving menstrual frequency and other symptoms of patients with PCOS. The limitation of this trial is that it would be difficult to blind the acupuncturists. In addition, these findings may not be suitable for women with PCOS who are seeking pregnancy.

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“…Many studies have limitations, including failure to report important clinical outcomes, poor reporting of study methods, non-randomised controlled studies, small sample size and insufficient information on allocation concealment in randomised clinical trials; even the latest systematic review and meta-analysis still came to the conclusion that there is currently insufficient evidence to support the use of acupuncture for treatment of ovulation disorders in women with PCOS. 3 4 …”

Section: Contextmentioning

confidence: 99%