Acupuncture ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia through Nrf2-mediated antioxidant response

Wang, Xuerui; Shi, Guang‐Xia; Yang, Jing‐Wen; Yan, Chao-Qun; Lin, Li-Ting; Du, Shoucheng; Zhu, Wenxu; He, Tianbiao; Zeng, Xiang; Xu, Qian; Liu, Cun‐Zhi

doi:10.1016/j.freeradbiomed.2015.10.426

Cited by 77 publications

(84 citation statements)

References 48 publications

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“…Oxidative stress is the result of a disequilibrium of pro‐oxidant and antioxidant systems, which have been well documented in the pathophysiology of CCH‐induced cognitive dysfunction . Acupuncture has proven to have the ability to suppress oxidative stress in many diseases including VD . Our previous study demonstrated that the major ROS‐producing enzyme, NADPH oxidase, was suppressed by acupuncture in VD rats .…”

Section: Discussionmentioning

confidence: 95%

“…32 Acupuncture has proven to have the ability to suppress oxidative stress in many diseases including VD. 16,33,34 Our previous study demonstrated that the major ROS-producing enzyme, NADPH oxidase, was suppressed by acupuncture in VD rats. 20 In this study, we found that overproduction of ROS and 8-OHdG and SOD inhibitory activity induced by 2VO were reversed by acupuncture treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Acupuncture is widely accepted as a complementary and alternative medicinal therapy, which has proven effective in many neurological diseases, including VD . Studies have also provided evidence that acupuncture could promote stroke rehabilitation .…”

Section: Introductionmentioning

confidence: 99%

“…14,15 Acupuncture is widely accepted as a complementary and alternative medicinal therapy, which has proven effective in many neurological diseases, including VD. [16][17][18] Studies have also provided evidence that acupuncture could promote stroke rehabilitation. 19 Our previous studies found that improving the cognition of 2VO rats could be achieved by acupuncture via inhibiting O2-production.…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats

et al. 2017

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats

et al. 2017

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“…A). It was known that polymorphisms of the Nrf2 gene had effects on the affinity and expression of the Nrf2 proteins and activation of the Nrf2 . Among the previous studies on single nucleotide polymorphisms (SNPs) of the Nrf2 gene, the polymorphisms of Nrf2 promoter region paly a major role in affecting its transcriptional activity.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations

Song

Liu

et al. 2016

J Cellular Molecular Medi

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The nuclear factor erythroid‐derived two‐like 2‐antioxidant response element (Nrf2‐ARE) pathway and its downstream antioxidant enzyme heme oxygenase‐1 (HMOX1 or HO‐1) play essential roles in H2O2‐induced oxidative damage in human melanocytes. However, the link between Nrf2 promoter polymorphisms and susceptibility to oxidative stress‐related diseases such as vitiligo is unknown. This study evaluated the association of the Nrf2 and HO‐1 genes polymorphisms with vitiligo susceptibility. In this case–control study of 1136 Han Chinese vitiligo patients and 1200 controls, Nrf2 (rs35652124 and rs6721961) and HO‐1 (rs2071746) genes were genotyped by PCR‐restriction fragment length polymorphism analysis. Overall, a significantly decreased risk of vitiligo was found to be associated with Nrf2 rs35652124 CC and combined (CT+CC) genotypes [odds ratio (OR) 0.64, 95% confidence interval (CI) 0.50–0.83 and OR, 0.84, 95% CI 0.71–0.99, respectively], as well as among subgroups: female, onset age ≤20 and never smoker. We subsequently found that Nrf2 rs35652124 C allele had higher transcriptional activity in the luciferase reporter assay compared with Nrf2 rs35652124 T allele. Furthermore, we investigated serum HO‐1 activity was associated with the rs35652124 CT+CC genotype and lower in patients than in controls (P = 0.024). Logistic regression analysis showed a dose–response relationship between lower vitiligo risk and increased HO‐1 activity in rs35652124 CT+CC genotype carriers (P trend < 0.05). These findings indicate that the C allele of rs35652124 located in the promoter region of Nrf2 gene is associated with protective effect on vitiligo in a Han Chinese population.

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Standardizing therapeutic parameters of acupuncture in vascular dementia rats

Yang

et al. 2020

Brain and Behavior

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Vascular dementia (VD) is a heterogeneous group of brain disorders associated with loss of memory and cognitive function resulting from vascular lesions. It is the second leading cause of cognitive impairment after Alzheimer's disease (AD) in the elderly (Du et al., 2013). In developing countries, VD accounts for approximately 30% of the age-adjusted dementia prevalence and in Western countries (Kalaria et al., 2008), the rate of VD is approximately1%-4% in people at the age of 65 (McVeigh & Passmore, 2006). The WHO estimates that 50 million people have dementia, a number that is anticipated to triple by 2050. As people live longer, the burden of

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Acupuncture ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia through Nrf2-mediated antioxidant response

Cited by 77 publications

References 48 publications

Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats

Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats

Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations

Standardizing therapeutic parameters of acupuncture in vascular dementia rats

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