Activity of Schisandrin C Isolated from<i>Schisandra chinensis</i>against Human Cancer Cell Lines

Lü, Yanhua; Liang, Xin‐hua; Wei, Dongzhi; Wang, Zhengtao

doi:10.1080/13880200802370399

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…It was further demonstrated by MTT assay that it also has an excellent sensitizing anti‐gastric cancer activity of 5‐FU in vitro [84] . In addition, C. Park [85] reported its antitumor activity by inhibiting the growth of U937 cells, blocking the cycle and inducing apoptosis, and Y. Lu [86] reported that it better inhibited the growth of liver cancer cells (Bel‐7402) [IC 50 with 81.58±1.06 μmol/L].…”

Section: Bioactivitymentioning

confidence: 99%

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

Xu,

Wang,

et al. 2023

Chemistry & Biodiversity

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Since ancient times, China has used natural medicine as the primary way to combat diseases and has a rich arsenal of natural medicines. With the progress of the times, the extraction of bioactive molecules from natural drugs has become the new development direction for natural medicines. Among the numerous natural drugs, Schisandrin C (Sch C), derived from Schisandra Chinensis (Turcz.) Baill. It has excellent potential for development and has been shown to possess various pharmacological properties, including hepatoprotective, antitumor and anti‐inflammatory activities. Based on the biological properties of hepatoprotection, scholars have explored Sch C and its synthetic products in depth; some studies have shown that pentosidine has the effect of improving the symptoms of liver fibrosis and reducing the concentration of alanine transaminase (ALT) and aspartate aminotransferase (AST) in the serum of rats, which is an essential inspiration for the development of anti‐liver fibrosis drugs. But more in vivo and ex vivo studies still need to be included. This paper focuses on Sch C′s extraction and synthesis, biological activities and drug development progress. The future application prospects of Sch C are discussed to perfect its development work further.

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Section: Bioactivitymentioning

confidence: 99%

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

Xu,

Wang,

et al. 2023

Chemistry & Biodiversity

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“…Sch C, also referred to as wuweizisu C, was initially identified as a hepatoprotective agent [ 93 ]. Lu et al [ 94 ] isolated and reported the selective anticancer activity of Sch C towards hepatocellular carcinoma cells (Bel-7402), compared to a breast cancer cell line (Bcap37) and a nasopharyngeal carcinoma cell line (KB-3-1). Sch C also exhibited anticancer activity against human leukemia U937 cells, where it induced cell cycle arrest and apoptosis [ 95 ].…”

Section: Natural Polyphenols and Their Anticancer Propertiesmentioning

confidence: 99%

Ellagic Acid and Schisandrins: Natural Biaryl Polyphenols with Therapeutic Potential to Overcome Multidrug Resistance in Cancer

Yoganathan

Alagaratnam

Acharekar

et al. 2021

Cells

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Multidrug resistance (MDR) is one of the major clinical challenges in cancer treatment and compromises the effectiveness of conventional anticancer chemotherapeutics. Among known mechanisms of drug resistance, drug efflux via ATP binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) has been characterized as a major mechanism of MDR. The primary function of ABC transporters is to regulate the transport of endogenous and exogenous small molecules across the membrane barrier in various tissues. P-gp and similar efflux pumps are associated with MDR because of their overexpression in many cancer types. One of the intensively studied approaches to overcome this mode of MDR involves development of small molecules to modulate P-gp activity. This strategy improves the sensitivity of cancer cells to anticancer drugs that are otherwise ineffective. Although multiple generations of P-gp inhibitors have been identified to date, reported compounds have demonstrated low clinical efficacy and adverse effects. More recently, natural polyphenols have emerged as a promising class of compounds to address P-gp linked MDR. This review highlights the chemical structure and anticancer activities of selected members of a structurally unique class of ‘biaryl’ polyphenols. The discussion focuses on the anticancer properties of ellagic acid, ellagic acid derivatives, and schisandrins. Research reports regarding their inherent anticancer activities and their ability to sensitize MDR cell lines towards conventional anticancer drugs are highlighted here. Additionally, a brief discussion about the axial chirality (i.e., atropisomerism) that may be introduced into these natural products for medicinal chemistry studies is also provided.

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“…Former pharmacological investigations on schisandrol B have documented various activities of shisandrol B including liver enlargement (PMID: 33662920), amelioration of metastatic melanoma (PMID: 32028184), anti-inflammatory activities (PMID: 29423034, PMID: 24749675, PMID: 24211520), hepatoprotective activity (PMID: 28128437, PMID: 25753323), PCSK9 mRNA expression inhibition (PMID: 28139296), and promotion of liver regeneration (PMID: 29066412). Previous studies on the bioactivity of schisandrin C have indicated that schisandrin C exhibits anti-inflammatory [12,13], anti-cancer activity [14], anti-oxidative activity [15], hepatoprotective activity [PMID: 25753323], inhibitory activity against PCSK9 mRNA expression [PMID: 28139296], lipid-lowering activity [16], and neuroprotective activity (PMID: 26074330, PMID: 20740476) activity. In addition, schisandrin C regulates inflammatory factors in diabetic mice, thereby attenuating nephropathy, which is a major complication of diabetes [17].…”

Section: Introductionmentioning

confidence: 99%

Schisandrin C Affects Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells and Glucose Uptake in Skeletal Muscle Cells

Lee

Kim

et al. 2021

Molecules

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The aim of our study was to investigate the effect of three lignans (schisandrol A, schisandrol B, and schisandrin C) on insulin secretion in rat INS-1 pancreatic β-cells and glucose uptake in mouse C2C12 skeletal muscle cells. Schisandrol A and schisandrin C enhanced insulin secretion in response to high glucose levels with no toxic effects on INS-1 cells. The effect of schisandrin C was superior to that of gliclazide (positive control), a drug commonly used to treat type 2 diabetes (T2D). In addition, western blot analysis showed that the expression of associated proteins, including peroxisome proliferator-activated receptor γ (PPARγ), pancreatic and duodenal homeobox 1 (PDX-1), phosphatidylinositol 3-kinase (PI3K), Akt, and insulin receptor substrate-2 (IRS-2), was increased in INS-1 cells after treatment with schisandrin C. In addition, insulin secretion effect of schisandrin C were enhanced by the Bay K 8644 (L-type Ca2+ channel agonist) and glibenclamide (K+ channel blocker), were abolished by the nifedipine (L-type Ca2+ channel blocker) and diazoxide (K+ channel activator). Moreover, schisandrin C enhanced glucose uptake with no toxic effects on C2C12 cells. Western blot analysis showed that the expression of associated proteins, including insulin receptor substrate-1 (IRS-1), AMP-activated protein kinase (AMPK), PI3K, Akt, glucose transporter type 4 (GLUT-4), was increased in C2C12 cells after treatment with schisandrin C. Schisandrin C may improve hyperglycemia by enhancing insulin secretion in pancreatic β-cells and improving glucose uptake into skeletal muscle cells. Our findings may provide evidence that schisandrin C may be beneficial in devising novel anti-T2D strategies.

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Activity of Schisandrin C Isolated fromSchisandra chinensisagainst Human Cancer Cell Lines

Cited by 5 publications

References 30 publications

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

Ellagic Acid and Schisandrins: Natural Biaryl Polyphenols with Therapeutic Potential to Overcome Multidrug Resistance in Cancer

Schisandrin C Affects Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells and Glucose Uptake in Skeletal Muscle Cells

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