Activity of caffeic acid derivatives against Candida albicans biofilm

Ethyl Cinnamate Derivatives as Promising High-Efficient Acaricides against <i>Psoroptes cuniculi</i>: Synthesis, Bioactivity and Structure–Activity Relationship

“…Although the similar case was also found for HIV-1 integrase activity of cinnamic acid esters, 53) the double bond was thought to be crucial for other bioactivities such as leishmanicidal and cytotoxic, 38) antituberculosis (TB) 22,24) and anti-candida albicans biofilm. 16) The leishmanicidal and cytotoxic action of cinnamic acid esters had been explained as a Michael addition mechanism, 38) in which cinnamic acid esters as one type of α,β-unsaturated carbonyl compounds were considered to have a conjugated addition reaction with nucleophilic groups in biomolecules of the natural receptors. This mechanism was also reported for other α,β-unsaturated carbonyl compounds such as lactones, chalcones and coumarins.…”

“…10) Due to their common occurrence in plants and their low toxicity, 11,12) cinnamic acid derivatives have attracted much attention of many pharmacologists. In the past decades, cinnamic acid derivatives including natural, semi-synthetic and synthetic compounds had been proven to have a variety of pharmacological activities, 13) such as anticancer, 14,15) antimicrobial, [16][17][18] antioxidative, 18) anti-inflammatory, 15,[19][20][21] anti-Mycobactrium tuberculosis, [22][23][24] antiviral, 25) anti-human immunodeficiency virus (HIV), [26][27][28] antidiabetic, 29) anticholesterolemic, 30) analgesic, 31) hepatoprotective, 32,33) immunoprotective, 34) inducing neural progenitor cell proliferation 35) and anxiolytic activity. 36) Especially, what interests us is that cinnamic acid derivatives also have significant antiparasitic activities on plasmodia, 37) Leishmania 38) and nematode.…”

In vitroantifungal activity of extracts obtained fromHypericum perforatumadventitious roots cultured in a mist bioreactor against planktonic cells and biofilm ofMalassezia furfur

“…The resistance of the biofilm led to search for new antifungal agents (De Vita et al 2014). Fungal biofilm is ubiquitous, located all over the human host, including the oral cavity, respiratory tract, gastrointestinal tract, urinary tract, wounds and upon biomedical devices.…”

Assessment of the encapsulation effect of phenolic compounds from Spirulina sp. LEB-18 on their antifusarium activities

“…Caffeic acid, along with gallic acid can also inhibit fungi biofilm, responsible for secondary infections with high mortality (Wang, Cheng, Guan, Wang & Yun, 2009;De Vita et al, 2014). Structure-activity analyses indicate that conjugation of the ester group with an unsaturated system has an important structural role for the microbial biofilm inhibition (De Vita et al, 2014). Gallic acid seems to inhibit the 15 biofilm initial adherence and filamentous growth (Wang et al, 2009).…”

“…Other fungi enzyme inhibited by caffeic acid is the isocitrate lyase, the catalyst of the glyoxylate cycle first step (Cheah, Lim & Sandai, 2014). Caffeic acid, along with gallic acid can also inhibit fungi biofilm, responsible for secondary infections with high mortality (Wang, Cheng, Guan, Wang & Yun, 2009;De Vita et al, 2014). Structure-activity analyses indicate that conjugation of the ester group with an unsaturated system has an important structural role for the microbial biofilm inhibition (De Vita et al, 2014).…”