Activities of some glycolytic enzymes in the major salivary glands of some laboratory animals

Metabolic remodeling triggered by salivation and diabetes in major salivary glands

“…An understanding of the metabolic fundamentals of these very important organs is of paramount importance in the determination of their function in various pathologies which undermine saliva production and affect the overall quality of life of patients. Some information exists concerning the general glycolytic and oxidative characters of major glands . Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process.…”

“…Some information exists concerning the general glycolytic and oxidative characters of major glands. 8,22 Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process. In this study, and for the first time, a 13 C NMR isotopomer analysis was performed in vivo in order to determine: (i) the occurrence of glycolysis and Krebs' cycle fluxes in SM and PA glands, both at rest and on stimulation, and the key metabolic characters of each gland; (ii) the degree of coupling between the two above-mentioned pathways and its response driven by stimulation;…”

Metabolic remodeling triggered by salivation and diabetes in major salivary glands

“…An understanding of the metabolic fundamentals of these very important organs is of paramount importance in the determination of their function in various pathologies which undermine saliva production and affect the overall quality of life of patients. Some information exists concerning the general glycolytic and oxidative characters of major glands . Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process.…”

“…Some information exists concerning the general glycolytic and oxidative characters of major glands. 8,22 Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process. In this study, and for the first time, a 13 C NMR isotopomer analysis was performed in vivo in order to determine: (i) the occurrence of glycolysis and Krebs' cycle fluxes in SM and PA glands, both at rest and on stimulation, and the key metabolic characters of each gland; (ii) the degree of coupling between the two above-mentioned pathways and its response driven by stimulation;…”

Influência do Estado Diabético Sobre a Atividade e Distribuição das Enzimas Hexoquinase e Fosfofrutoquinase-1 nas Glândulas Submandibular e Parótida de Ratos

“…Quando se estuda o metabolismo em glândulas salivares, o tipo glandular e a espécie de animal mostra grande importância. No estudo de Nicolau et al (1974) foi mostrado que a atividade específica de algumas enzimas variavam entre as espécies e entre as glândulas dos animais, concluindo que não se deve generalizar os resultados obtidos em uma glândula para todas as três.…”

Metabolic remodeling triggered by salivation and diabetes in major salivary glands

“…An understanding of the metabolic fundamentals of these very important organs is of paramount importance in the determination of their function in various pathologies which undermine saliva production and affect the overall quality of life of patients. Some information exists concerning the general glycolytic and oxidative characters of major glands . Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process.…”

“…Some information exists concerning the general glycolytic and oxidative characters of major glands. 8,22 Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process. In this study, and for the first time, a 13 C NMR isotopomer analysis was performed in vivo in order to determine: (i) the occurrence of glycolysis and Krebs' cycle fluxes in SM and PA glands, both at rest and on stimulation, and the key metabolic characters of each gland; (ii) the degree of coupling between the two above-mentioned pathways and its response driven by stimulation;…”

Influência do Estado Diabético Sobre a Atividade e Distribuição das Enzimas Hexoquinase e Fosfofrutoquinase-1 nas Glândulas Submandibular e Parótida de Ratos

“…Quando se estuda o metabolismo em glândulas salivares, o tipo glandular e a espécie de animal mostra grande importância. No estudo de Nicolau et al (1974) foi mostrado que a atividade específica de algumas enzimas variavam entre as espécies e entre as glândulas dos animais, concluindo que não se deve generalizar os resultados obtidos em uma glândula para todas as três.…”

Metabolic remodeling triggered by salivation and diabetes in major salivary glands

“…An understanding of the metabolic fundamentals of these very important organs is of paramount importance in the determination of their function in various pathologies which undermine saliva production and affect the overall quality of life of patients. Some information exists concerning the general glycolytic and oxidative characters of major glands . Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process.…”

“…Some information exists concerning the general glycolytic and oxidative characters of major glands. 8,22 Unfortunately, it is very limited in terms of the dynamic character of such metabolic pathways and their overall involvement in the physiological process. In this study, and for the first time, a 13 C NMR isotopomer analysis was performed in vivo in order to determine: (i) the occurrence of glycolysis and Krebs' cycle fluxes in SM and PA glands, both at rest and on stimulation, and the key metabolic characters of each gland; (ii) the degree of coupling between the two above-mentioned pathways and its response driven by stimulation;…”

Influência do Estado Diabético Sobre a Atividade e Distribuição das Enzimas Hexoquinase e Fosfofrutoquinase-1 nas Glândulas Submandibular e Parótida de Ratos

“…Quando se estuda o metabolismo em glândulas salivares, o tipo glandular e a espécie de animal mostra grande importância. No estudo de Nicolau et al (1974) foi mostrado que a atividade específica de algumas enzimas variavam entre as espécies e entre as glândulas dos animais, concluindo que não se deve generalizar os resultados obtidos em uma glândula para todas as três.…”