2017
DOI: 10.3892/ol.2017.7584
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Abstract: Abstract. Activin A is a pleiotropic cytokine belonging to the transforming growth factor β superfamily. Abnormal expression of activin A is associated with tumorigenesis. Multiple myeloma is characterized by the development of osteolytic disease, which ultimately leads to cachexia. However, the involvement of activin A in myeloma cell viability and apoptosis remains to be fully elucidated. For this purpose, mouse myeloma NS-1 cells were treated with activin A, and subsequently subjected to 5-bromo-2'-deoxyuri… Show more

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Cited by 6 publications
(35 citation statements)
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References 30 publications
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“…By contrast, its biological and clinical significances in hematological malignancies remain controversial. Activin A was reported to cause apoptosis of myeloma cells and chronic myeloid leukemia cells (10,11). On the other hand, similar to our results, high expression of βA subunit, which composes activin A, is an adverse prognostic factor for acute myeloid leukemia (12).…”
Section: Discussionsupporting
confidence: 90%
“…By contrast, its biological and clinical significances in hematological malignancies remain controversial. Activin A was reported to cause apoptosis of myeloma cells and chronic myeloid leukemia cells (10,11). On the other hand, similar to our results, high expression of βA subunit, which composes activin A, is an adverse prognostic factor for acute myeloid leukemia (12).…”
Section: Discussionsupporting
confidence: 90%
“…Circulating activin A levels are elevated in patients with advanced multiple myeloma, and MSCs and osteoblasts are the main sources of activin A (19,20). Previous studies have revealed that activin A induces apoptosis in mouse myeloma NS-1 cells via the mitochondrial pathway by increasing the expression of cleaved caspase-3 and Cyt c proteins and the ratio of Bax/Bcl-2 (18). However, whether activin A can induce NS-1 cell apoptosis via the ER stress pathway is still unclear.…”
Section: Discussionmentioning
confidence: 99%
“…The ER is a membranous compartment present in eukaryotic cells, which controls the synthesis, folding, and trafficking of proteins to be secreted, as well as calcium storage and synthesis of membranes. Previous studies reported that activin A can induce B-cell apoptosis associated with Smad3 (25), and induce NS-1 cell apoptosis mediated by the mitochondrial pathway (18). However, whether the ER stress pathway is involved in activin A-induced NS-1 cell apoptosis is still unclear.…”
Section: Discussionmentioning
confidence: 99%
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“…The rt‐qPCR results showed that the activin β A and activin β B genes were widely expressed in the tested tissues (Figure ), in accordance with previous reports (Daopin et al ., ). Activin has an effect not only on reproductive processes but also on the inflammatory response; protection of neurons; cell proliferation, differentiation and apoptosis; embryonic development; and bone remodelling (Sakai et al ., ; Vanttinen et al ., ; Y. Zhang et al ., ). Its broad expression pattern indicates that activin is a multifunctional growth factor and acts as an autocrine and paracrine modulator.…”
Section: Primers Used In This Study Of Rcc and Accmentioning
confidence: 97%