volume 192, issue 3, P1241-1248 2014
DOI: 10.4049/jimmunol.1301487
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Pascal Seeger, Daniela Bosisio, Silvia Parolini, Raffaele Badolato, Angela Gismondi, Angela Santoni, Silvano Sozzani

Abstract: The interaction of NK cells with dendritic cells (DCs) results in reciprocal cell activation through the interaction of membrane proteins and the release of soluble factors. In this article, we report that in NK-DC cocultures, among a set of 84 cytokines investigated, activin A was the second highest induced gene, with CXCL8 being the most upregulated one. Activin A is a member of the TGF-beta superfamily and was previously shown to possess both proinflammatory and anti-inflammatory activities. In NK-DC cocult…

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