2017
DOI: 10.1016/j.biomaterials.2017.03.019
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Abstract: Stable interconnection to neurons in vivo over long time-periods is critical for the success of future advanced neuroelectronic applications. The inevitable foreign body reaction towards implanted materials challenges the stability and an active intervention strategy would be desirable to treat inflammation locally. Here, we investigate whether controlled release of the anti-inflammatory drug Dexamethasone from flexible neural microelectrodes in the rat hippocampus has an impact on probe-tissue integration ove… Show more

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Cited by 155 publications
(152 citation statements)
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“…This may be a simpler approach than using a cylinder-shaped shuttle, e.g. tungsten wire or carbon wire 32,33 where the fabrication is expensive and does not scale to multi-shank devices.…”
Section: Advantages Of T-uncd Over Other Shuttle Approachesmentioning
confidence: 99%
See 1 more Smart Citation
“…This may be a simpler approach than using a cylinder-shaped shuttle, e.g. tungsten wire or carbon wire 32,33 where the fabrication is expensive and does not scale to multi-shank devices.…”
Section: Advantages Of T-uncd Over Other Shuttle Approachesmentioning
confidence: 99%
“…A flexible electrode array was fabricated broadly as we and others have described 33,54 . One layer of 2.2 µm-thick polyimide (PI-2610 from HD Microsystems) was spin-coated on a sacrificial layer and fully cured at 350˚C.…”
Section: Polymer Array Fabricationmentioning
confidence: 99%
“…These values are in accordance with CSC data recently reported by C. Boehler et al. for neural implants coated with PEDOT–DEX for a chronic in vivo neural recording study …”
Section: Resultsmentioning
confidence: 99%
“…To realize a long-term reliable neuro-electrode interface, it seems essential to minimize the foreign body response (Nguyen et al, 2014;Potter et al, 2014;Sohal, Clowry, Jackson, O'Neill, & Baker, 2016;Winslow & Tresco, 2010). To this end, many approaches have been proposed and investigated including innovations on bio-compatible flexible materials (Luan et al, 2017;Nguyen et al, 2014;Richter et al, 2013;Rousche et al, 2001;Rubehn, Lewis, Fries, & Stieglitz, 2010;Sohal et al, 2016;Stieglitz & Meyer, 1998;Takeuchi, Suzuki, Mabuchi, & Fujita, 2004;Böhler et al, 2017), decreasing implant size (Khilwani et al, 2017;Patel et al, 2015Patel et al, , 2016Ferro et al, 2018) or surface modifications by coating the device with anti-inflammatory drugs that will actively release (Azemi, Lagenaur, & Cui, 2011;Boehler et al, 2017;Eles et al, 2017;Kolarcik et al, 2012;Potter et al, 2014).…”
Section: Introductionmentioning
confidence: 99%