Active Surveillance on the Use of Antibiotics in Children, Particularly in the Age Group from 0 to 2 Years

Napoleone, Ettore; Lavalle, Antonella; Scasserra, Cristiana; Ricci, M.

doi:10.4172/2329-6887.1000205

Cited by 2 publications

(6 citation statements)

References 16 publications

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“…In the study on the antibiotics [21][22][23], after a comparison of prescriptive data of 2013 and the year 2015 after the formation of family pediatricians and the information to families on the proper use of antibiotics and of any adverse events related to their misuse, we had:…”

Section: Discussionmentioning

confidence: 99%

“…AIFA (The Italian medicines agency) approved, for the first time ever, a project conceived, structured and implemented by the family pediatricians and presented by the Molise region, within the program of active pharmacovigilance funded through the regional funds available for the years 2008 and 2009 [20,21].…”

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

“…It still seems obvious that inefficient use of these drugs as instructed are not always based on scientific evidence raising the problem of antibiotics-strength and quality of the therapy. Hence the need for a research project, Phase IV, is managed and coordinated in full for the first time with the family pediatrician, that can foresee on one hand training and information regarding the proper use of antibiotics in children and possible iatrogenic pathologies caused by their improper use, the other to 318 constitute a appropriaten aimed at eva The study w data OSME track the dia and of a c various pedi [21][22][23].…”

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

“…It then proceeded to give relief to these aspects of inappropriateness prescriptive disseminating the main aspects of national and international guidelines for paediatricians. In particular, it was forwarded, as shown in the international guidelines (NICE 2008(NICE -2015, in the case of a child with a sore throat, that though there are other signs of infection concomitant respiratory tract (nasal discharge, cough) it is certainly a viral disease [20][21][22][23].…”

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

“…Overall, the importance of proper training is clear for paediatrician's appropriateness of prescribing antibiotics for this vulnerable class of children, correct information for families on knowledge and experience of pediatric medication and the importance of always consulting the pediatrician before "misuse" of medication that do not resolve the clinical solution but rather expose these young patients at risk [21][22][23].…”

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

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ADRs and Children: Knowledge and Methodological Standard in PASS (Post Authorization Safety Studies)

Napoleone¹,

Scasserra²

2017

JPP

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PhV (pharmacovigilance) knowledge has the outcome of being inadequate in particular due to the lack of instruction. Pediatricians have to face the realization that over-the-counter medicines increments the peril of ADRs (adverse drug reactions) has become a public health concern. The purpose of this article is to disseminate knowledge of the PhV and to highlight the cultural and organizational difficulties for its implementation. The objectives of promoting the organization of specific training courses and research projects aimed at: (1) to foster the culture of iatrogenic disease in pediatrics; (2) to improve the appropriateness of prescribing drugs in children; (3) to encourage spontaneous reporting of ADRs in children; (4) to involve Pediatricians in PASS (post-authorization safety studies) according to GCP, GVP and ENCEPP Code of Conduct. An up to date proposal of PhV, a procedure of preparation improves the productivity of creating novel informative reports which can be utilized for a benefit/risk scrutiny making strides in medicine prescription. In this context, FP-MCRN (family paediatricians-medicines for children research network) established with the aim of developing competence, infrastructure and education for paediatric clinical trials, plays a crucial role in paediatric PhV, through an improvement of PhV training, a correct research methodology and very strong relationship with the families. The initial necessity is cultural, implementing culture of iatrogenic illnesses and a watchful evaluation of the importance of PASS by FPs (family pediatricians). Participation in clinical trials that generates a precise database administered by FPs together with follow-up outcomes becomes relevant and vital for a scrupulous and accurate assessment of ADRs. PASS can foresee on one hand training and information regarding the proper use of drugs in children and possible iatrogenic pathologies caused by their improper use, the other to constitute a territorial survey in the prescriptive appropriateness and safety of pediatric drugs aimed at evaluating the risk-benefit balance on usage.

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Section: Discussionmentioning

confidence: 99%

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

Section: Pass (Post-authorization Safety Studies)mentioning

confidence: 99%

See 3 more Smart Citations

ADRs and Children: Knowledge and Methodological Standard in PASS (Post Authorization Safety Studies)

Napoleone¹,

Scasserra²

2017

JPP

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REDS (Respiratory Drugs Survey) Study. Active Surveillance of Respiratory Drugs and in Particular of Inhaled Steroids (IS) in the Paediatric Age

Napoleone¹,

Lavalle

Scasserra³

et al. 2018

Int. J. Pediatr. Child Health

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Background and aims: Inhaled Steroids (IS) are used inappropriately for children who have been "over prescribed" for conditions such as colds, coughs and sore throats. This practice is not always based on scientific evidence. IS have a modest effectiveness in preventing both recurrent wheezing, viral and bronchiolitis in children. The aim of the study is to monitor the use of IS with careful analysis of the risk / benefit factor of the treatment, through accuracy of diagnosis, the therapeutic appropriateness and the safe use of these medications. Methods: In this epidemiological / observational (case-study) and active observational project, the prescribing data for children (0-14 yrs) were collected and processed by Family Pediatricians (FPs). The activities have been divided into four sections: 1) Elaboration of the prescriptive data (year 2015-retrospective) 2) Training / information events for FPs and families on the correct use of IS (year 2016) 3) Elaboration of the prescriptive data of the same FPs after the training year (year 2017-prospective) 4) Comparison of the prescriptive data of IS in the age group of 0 - 14 years in the years 2015 and 2017 (before and after the training phase) Results: After the training phase: the prevalence of use of IS decreased from 20.71% to 15.15% ; the percentage of the appropriate prescriptions increased from 30.65% to 58.02% ; the percentage of the inappropriate prescriptions decreased from 68.67 % to 38.66%; the prevalence of inappropriate prescriptions decreased : a) in the 0-4 yrs from 70.24% to 39.30%; b) in the 5-10 yrs from 66.31% to 35.95%, and c) in the 11-14 yrs from 69.80% to 35.04%; the percentage of inappropriate expenditure decreased from 67.31% to 37.63%; the percentages of inappropriate prescriptions decreased for Beclomethasone from 71.47% to 38.29%, for Budesonide from 69.82% to 43.29%, for Fluticasone from 53.84% to 19.01% and for Flunisolide from 70.45% to 56.93% ; the total number of pieces prescribed decreased from 4.338 to 3.148. Conclusions: We have highlighted that through training courses for Family Pediatricians and a correct information to families a significant improvement in the use of Inhaled Steroids can be achieved.

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Active Surveillance on the Use of Antibiotics in Children, Particularly in the Age Group from 0 to 2 Years

Cited by 2 publications

References 16 publications

ADRs and Children: Knowledge and Methodological Standard in PASS (Post Authorization Safety Studies)

ADRs and Children: Knowledge and Methodological Standard in PASS (Post Authorization Safety Studies)

REDS (Respiratory Drugs Survey) Study. Active Surveillance of Respiratory Drugs and in Particular of Inhaled Steroids (IS) in the Paediatric Age

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