Biochemical Pharmacology volume 80, issue 9, P1309-1316 2010 DOI: 10.1016/j.bcp.2010.06.048 View full text
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Shala L. Thomas, Jing Zhao, Zijian Li, Bin Lou, Yuhong Du, Jamie Purcell, James P. Snyder, Fadlo R. Khuri, Dennis Liotta, Haian Fu

Abstract: Increasing attention has been given to the anti-cancer effects of curcumin and the ability of this natural product to inhibit cancer cell proliferation. New curcumin analogs have been developed to optimize the in vitro and in vivo activity of the parent compound yet retain the same safety profile. EF24, a fluorinated synthetic analog, surpasses curcumin in its ability to inhibit cancer cell viability and down-regulate TNFα-induced NF-κB activation. Here we report a critical role of the p38-mediated signaling …

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