volume 66, issue 6, P3961-3965 1992
DOI: 10.1128/jvi.66.6.3961-3965.1992
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D M Markovitz, M C Hannibal, M J Smith, R Cossman, G J Nabel

Abstract: The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the KB sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.