Activation of the DLPFC Reveals an Asymmetric Effect in Risky Decision Making: Evidence from a tDCS Study

Huang, Daqiang; Chen, Shu; Wang, Siqi; Shi, Jinchuan; Ye, Hang; Luo, Jun; Zheng, Haoli

doi:10.3389/fpsyg.2017.00038

Cited by 21 publications

(75 citation statements)

References 65 publications

(75 reference statements)

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“…Two independent reviewers excluded 908 records according to their titles and abstracts during the early stage of screening. Finally, 70 records were excluded during the full-text screening and data extraction, and 20 articles were evaluated as eligible studies: including 16 articles on tDCS, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] two on tACS, 31, 32 one on tPCS, 33 and one on highdefinition tDCS. 34 One of these articles was open label 15 and the remaining 19 were randomized controlled trials.…”

Section: Synthesized Findingsmentioning

confidence: 99%

Effects of transcranial direct current stimulation of prefrontal cortex on risk‐taking behavior

Khaleghi

Jahromi

Zarafshan

et al. 2020

Psychiatry Clin. Neurosci.

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Aim Recent cognitive neuroscience research shows that noninvasive brain stimulation can modify a wide range of behaviors in healthy people. Such regulation effects on human behaviors provide new insights into the neurobiology of cognitive processes and establish causal brain–behavior relations. Here, we aimed to examine the effects of transcranial electrical stimulation (TES) of the prefrontal cortex on risk‐taking. Methods We performed a systematic search on the PubMed, Web of Science, and Cochrane databases with appropriate keywords for original studies reporting the use of TES to modulate risk‐taking behavior in healthy individuals. Then, in the meta‐analysis phase, a random‐effects model was used to measure the pooled effect size (ES). Results Twenty articles were evaluated as eligible studies, including 16 articles on transcranial direct current stimulation (tDCS), two on transcranial alternating current stimulation, one on transcranial pulsed current stimulation, and one on high‐definition tDCS. A meta‐analysis showed a pooled estimated standardized ES of −0.20 (95% confidence interval [CI], –0.39 to −0.01), which indicates a small ES for active tDCS over the dorsolateral prefrontal cortex (DLPFC) in comparison to sham stimulation (z = 2.31, P = 0.03) in terms of less risky behaviors. Subgroup analysis showed that there is no significant ES for bilateral DLPFC stimulation (d = −0.01; 95%CI, –0.28 to 0.26), but a significant near‐medium ES for unilateral DLPFC stimulation (d = −0.41; 95%CI, –0.71 to −0.10). Conclusion Our findings support a significant impact of neuroregulation of the DLPFC on risk‐taking behavior in healthy individuals. Unilateral noninvasive electrical stimulation of the DLPFC can result in a conservative risk‐averse response style, probably through modulating plasticity of the relevant brain networks, including cortical and subcortical structures, as well as increasing subcortical dopaminergic activity.

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Section: Synthesized Findingsmentioning

confidence: 99%

Effects of transcranial direct current stimulation of prefrontal cortex on risk‐taking behavior

Khaleghi

Jahromi

Zarafshan

et al. 2020

Psychiatry Clin. Neurosci.

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“…1) confirmed that both DLPFC and OFC regions, particularly the left side of DLPFC, played significant and key roles in cognitive processing when subjects had to solve the NP regardless of difficulty levels. Several previous studies in the literature have reported that DLPFC is responsible for risky decision making (in non-business context) and cognitive control in terms of planning and working memory 5,12,14,15 . Our findings in this paper are consistent with those reported in these documents.…”

Section: Discussionmentioning

confidence: 99%

Neural correlates of newsvendor-based decision making in the human brain: An exploratory study to link neuroeconomics with neuroimaging using fNIRS

Wanniarachchi

Lang

Wang

et al. 2020

Preprint

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Neuroeconomics with neuroimaging is a novel approach involving economics and neuroscience.The newsvendor problem (NP) is a prevalent economics concept that may be used to map brain activations during NP-evoked risky decision making. In this study, we hypothesized that key brain regions responsible for NP are dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC). Twenty-seven human subjects participated in the study using 40 NP trials; the participants were randomly assigned to a group with a low-profit margin (LM) or high-profit margin (HM) treatment. Cerebral hemodynamic responses were recorded simultaneously during the NP experiments from all participants with a 77-channel functional Near-infrared Spectroscopy (fNIRS) system. After data preprocessing, general linear model was applied to generate brain activation maps, followed by statistical t-tests. The results showed that: (a) DLPFC and OFC were significantly evoked by NP versus baseline regardless of treatment types; (b) DLPFC and OFC were activated by HM versus baseline; and (c) DLPFC was activated during LM versus baseline.Furthermore, significant deactivation in right DLPFC was shown due to LM with respect to HM.This study affirms that DLPFC and OFC are two key cortical regions when solving NP. In particular, right DLPFC was found to be more deactivated under challenging risk decision making.

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“…Finally, the die rolling task, where participants can lie about money earned, has also been used during tDCS stimulation (Marechel et al, 2017) Fecteau et al, 2007). The Iowa Gambling Task has also been used Fecteau et al, 2007) as well as the Columbia Gambling Task (Pripfl et al, 2013) and other gambling tasks (Bell et al, 2016;Huang et al, 2017;Ye et al, 2015;Zheng et al, 2017). A riskiness study that incorporated tDCS and a driving simulation has also been done (Belli et al, 2008).…”

Section: Honestymentioning

confidence: 99%

A meta-analysis of the effects of transcranial direct current brain stimulation on multiple realms of social behavior

Bell¹

2017

Preprint

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This meta-analysis examines the effects of transcranial direct current brain stimulation (tDCS) applied to the prefrontal cortex on a variety of social behaviors including aggression, overeating, impulsivity, bias, honesty, and risk-taking. 48 studies were included in this meta-analysis, N=2,196. tDCS was found to have an overall effect size of d=-0.2, which means tDCS reduced the undesirable behavior by a small but significant amount. tDCS was most effective at reducing risk-taking behavior, bias, and overeating. tDCS was not significantly effective at reducing aggression, impulsivity, or dishonesty. Moderators such as brain region of interest, online versus offline stimulation, within versus between subjects designs, dose, and duration were examined. Publication bias was also examined with three different tools, and significant publication bias was found in the literature in this meta-analysis. These findings indicate high likelihood that many tDCS studies with null findings exist and have not been added to our published literature. Taken together, these results suggest that tDCS works better on some social behaviors than others, but overall, can reduce antisocial behavior by a small but significant amount.Keywords: transcranial direct current stimulation, meta-analysis, social psychology, prefrontal cortex, prosocial behavior

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Activation of the DLPFC Reveals an Asymmetric Effect in Risky Decision Making: Evidence from a tDCS Study

Cited by 21 publications

References 65 publications

Effects of transcranial direct current stimulation of prefrontal cortex on risk‐taking behavior

Effects of transcranial direct current stimulation of prefrontal cortex on risk‐taking behavior

Neural correlates of newsvendor-based decision making in the human brain: An exploratory study to link neuroeconomics with neuroimaging using fNIRS

A meta-analysis of the effects of transcranial direct current brain stimulation on multiple realms of social behavior

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