Activation of Human Nerves by Hyperventilation and Hypocalcemia

Protons regulate the excitability properties of rat myelinated sensory axons in vitro through block of persistent sodium currents

“…The clinical symptoms of hyperventilation‐induced alkalosis on peripheral nerve (such as paresthesias, fasciculations, or involuntary muscle contractions) have been attributed to hypocalcaemia ( Kugelberg, 1948 ; Macefield and Burke, 1991 ) , since plasma proteins can reduce the ionized (and physiologically relevant) fraction of calcium in an alkaline milieu. In our in vitro preparation, however, we also saw a clear increase in excitability as a reduction in pCO 2 produced an alkaline shift, but there were no plasma proteins to translate this into low ionized calcium.…”

Protons regulate the excitability properties of rat myelinated sensory axons in vitro through block of persistent sodium currents

“…The clinical symptoms of hyperventilation‐induced alkalosis on peripheral nerve (such as paresthesias, fasciculations, or involuntary muscle contractions) have been attributed to hypocalcaemia ( Kugelberg, 1948 ; Macefield and Burke, 1991 ) , since plasma proteins can reduce the ionized (and physiologically relevant) fraction of calcium in an alkaline milieu. In our in vitro preparation, however, we also saw a clear increase in excitability as a reduction in pCO 2 produced an alkaline shift, but there were no plasma proteins to translate this into low ionized calcium.…”

Isolated finger flexion: a novel form of focal neuromyotonia

“…Hyperventilation leading to decreased serum ionised calcium and alkalosis enhances neuromyotonia 22. In healthy subjects hypocalcaemia and ischaemia produce spasms with repetitive firing of motor units 23. The mechanism of ischaemia induced spasm is probably different from neuromyotonia although they both could be present in the same patient 24.…”

Latent tetany and neuromuscular excitability

“…dubletów. Podobne obserwacje poczynili -E. Kugelberg w roku 1948 [24], a w kolejnych latach między innymi J. Lefèbvre, J. Lerique i P. Chaumont (1960) [25] oraz C. Cales (1966) [26].…”

“…Pierwsze wątpliwości, czy próba tężyczkowa to tylko ocena patologii mięśni, pojawiły się już w roku 1948, kiedy ukazała się praca E. Klugberga [24]. Praca ta podkreślała niezwykle ważny aspekt badania EMG -jest to badanie nie tylko funkcji mięśni, ale i nerwów.…”

Protons regulate the excitability properties of rat myelinated sensory axons in vitro through block of persistent sodium currents

“…The clinical symptoms of hyperventilation‐induced alkalosis on peripheral nerve (such as paresthesias, fasciculations, or involuntary muscle contractions) have been attributed to hypocalcaemia ( Kugelberg, 1948 ; Macefield and Burke, 1991 ) , since plasma proteins can reduce the ionized (and physiologically relevant) fraction of calcium in an alkaline milieu. In our in vitro preparation, however, we also saw a clear increase in excitability as a reduction in pCO 2 produced an alkaline shift, but there were no plasma proteins to translate this into low ionized calcium.…”

Isolated finger flexion: a novel form of focal neuromyotonia

“…Hyperventilation leading to decreased serum ionised calcium and alkalosis enhances neuromyotonia 22. In healthy subjects hypocalcaemia and ischaemia produce spasms with repetitive firing of motor units 23. The mechanism of ischaemia induced spasm is probably different from neuromyotonia although they both could be present in the same patient 24.…”

Latent tetany and neuromuscular excitability

“…dubletów. Podobne obserwacje poczynili -E. Kugelberg w roku 1948 [24], a w kolejnych latach między innymi J. Lefèbvre, J. Lerique i P. Chaumont (1960) [25] oraz C. Cales (1966) [26].…”

“…Pierwsze wątpliwości, czy próba tężyczkowa to tylko ocena patologii mięśni, pojawiły się już w roku 1948, kiedy ukazała się praca E. Klugberga [24]. Praca ta podkreślała niezwykle ważny aspekt badania EMG -jest to badanie nie tylko funkcji mięśni, ale i nerwów.…”

Protons regulate the excitability properties of rat myelinated sensory axons in vitro through block of persistent sodium currents

“…The clinical symptoms of hyperventilation‐induced alkalosis on peripheral nerve (such as paresthesias, fasciculations, or involuntary muscle contractions) have been attributed to hypocalcaemia ( Kugelberg, 1948 ; Macefield and Burke, 1991 ) , since plasma proteins can reduce the ionized (and physiologically relevant) fraction of calcium in an alkaline milieu. In our in vitro preparation, however, we also saw a clear increase in excitability as a reduction in pCO 2 produced an alkaline shift, but there were no plasma proteins to translate this into low ionized calcium.…”

Isolated finger flexion: a novel form of focal neuromyotonia

“…Hyperventilation leading to decreased serum ionised calcium and alkalosis enhances neuromyotonia 22. In healthy subjects hypocalcaemia and ischaemia produce spasms with repetitive firing of motor units 23. The mechanism of ischaemia induced spasm is probably different from neuromyotonia although they both could be present in the same patient 24.…”

Latent tetany and neuromuscular excitability

“…dubletów. Podobne obserwacje poczynili -E. Kugelberg w roku 1948 [24], a w kolejnych latach między innymi J. Lefèbvre, J. Lerique i P. Chaumont (1960) [25] oraz C. Cales (1966) [26].…”

“…Pierwsze wątpliwości, czy próba tężyczkowa to tylko ocena patologii mięśni, pojawiły się już w roku 1948, kiedy ukazała się praca E. Klugberga [24]. Praca ta podkreślała niezwykle ważny aspekt badania EMG -jest to badanie nie tylko funkcji mięśni, ale i nerwów.…”