Biochemical Pharmacology volume 80, issue 11, P1632-1640 2010 DOI: 10.1016/j.bcp.2010.08.012 View full text
Susanne Schiffmann, Simone Ziebell, Jessica Sandner, Kerstin Birod, Klaus Deckmann, Daniela Hartmann, Sina Rode, Helmut Schmidt, Carlo Angioni, Gerd Geisslinger, Sabine Grösch

Abstract: Ceramides serve as bioactive molecules with important roles in cell proliferation and apoptosis. 4 Ceramides (Cer) with different N-acyl side chains (C 14:0-Cer-C 26:0-Cer) possess distinctive roles 5 in cell signaling and are differentially expressed in HCT-116 colon cancer cells. Celecoxib, a 6 selective cyclooxygenase-2 (COX-2) inhibitor, exhibiting antiproliferative effects, activates the 7 sphingolipid pathway. To elucidate the mechanism, HCT-116 cells were treated with 50 µM 8 celecoxib leading to a sign…

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