Susanne Schiffmann, Simone Ziebell, Jessica Sandner, Kerstin Birod, Klaus Deckmann, Daniela Hartmann, Sina Rode, Helmut Schmidt, Carlo Angioni, Gerd Geisslinger, Sabine Grösch
Abstract:Ceramides serve as bioactive molecules with important roles in cell proliferation and apoptosis. 4 Ceramides (Cer) with different N-acyl side chains (C 14:0-Cer-C 26:0-Cer) possess distinctive roles 5 in cell signaling and are differentially expressed in HCT-116 colon cancer cells. Celecoxib, a 6 selective cyclooxygenase-2 (COX-2) inhibitor, exhibiting antiproliferative effects, activates the 7 sphingolipid pathway. To elucidate the mechanism, HCT-116 cells were treated with 50 µM 8 celecoxib leading to a sign…
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