Activation of Cannabinoid-1 Receptors Disrupts Sensory Gating and Neuronal Oscillation: Relevance to Schizophrenia

Hajós, Mihály; Hoffmann, William E.; Kocsis, Bernát

doi:10.1016/j.biopsych.2007.12.005

Cited by 149 publications

(145 citation statements)

References 51 publications

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“…Acute cannabinoid exposure attenuates the power of neural oscillations recorded in vitro (Hajós et al, 2000(Hajós et al, , 2008 and in vivo, in freely moving animals (Robbe et al, 2006;Hajós et al, 2008;Kucewicz et al, 2011) and during working memory tasks (Kucewicz et al, 2011) by CB1R-mediated suppression of glutamate release from pyramidal neurons (Holderith et al, 2011;Sales-Carbonell et al, 2013). This CB1R-mediated attenuation of excitatory transmission preferentially suppresses the frequency and firing precision of fast-spiking GABAergic interneurons, resulting in smaller and less synchronized field potentials (Holderith et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Acute cannabinoid administration attenuates the power of oscillations (Hajós et al, 2000(Hajós et al, , 2008Robbe et al, 2006;Kucewicz et al, 2011) by acting at CB1Rs to suppress glutamate release from pyramidal neurons (Holderith et al, 2011;Sales-Carbonell et al, 2013). Furthermore, oscillations are suppressed in chronic marijuana users, particularly in those with an earlier age of onset of use (Skosnik et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Adolescent Cannabinoid Exposure Permanently Suppresses Cortical Oscillations in Adult Mice

Raver

Haughwout

Keller

2013

Neuropsychopharmacol

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Regular marijuana use during adolescence, but not adulthood, may permanently impair cognition and increase the risk for psychiatric diseases, such as schizophrenia. Cortical oscillations are integral for cognitive processes and are abnormal in patients with schizophrenia. We test the hypothesis that adolescence is a sensitive period because of the active development of cortical oscillations and neuromodulatory systems that underlie them. The endocannabinoid system upon which marijuana acts is one such system. Here we test the prediction that adolescent cannabinoid exposure alters cortical oscillations in adults. Using in vitro local field potential, in vivo electrocorticogram recordings and cognitive behavioral testing in adult mice, we demonstrate that chronic adolescent, but not adult, cannabinoid exposure suppresses pharmacologically evoked cortical oscillations and impairs working memory performance in adults. The later-maturing prefrontal cortex is more sensitive to adolescent exposure than the earlier-maturing, primary somatosensory cortex. These data establish a link between chronic adolescent cannabinoid exposure and alterations in adult cortical network activity that underlie cognitive processes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adolescent Cannabinoid Exposure Permanently Suppresses Cortical Oscillations in Adult Mice

Raver

Haughwout

Keller

2013

Neuropsychopharmacol

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“…Injections were administered at least 20 min into the experiment and data were recorded for another 60 min. Analyses were performed at 10 min intervals preinjection and postinjection (at least 10 min into the experiment and 30 min after injection, respectively), based on the time courses of behavioral (Lichtman et al, 1995;Wise et al, 2009) and network activity (Robbe et al, 2006;Hajó s et al, 2008;Robbe and Buzsáki, 2009) changes exerted by systemic injections of cannabinoid receptor agonists in rats. Five of the subjects were subsequently trained in an end-to-end T-maze spatial working memory task (for a description, see Jones and Wilson, 2005) after being food-restricted to 85% of free feeding body weight.…”

Section: Methodsmentioning

confidence: 99%

Dysfunctional Prefrontal Cortical Network Activity and Interactions following Cannabinoid Receptor Activation

Kucewicz¹,

Tricklebank²,

Bogacz³

et al. 2011

J. Neurosci.

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Coordinated activity spanning anatomically distributed neuronal networks underpins cognition and mediates limbic-cortical interactions during learning, memory, and decision-making. We used CP55940, a potent agonist of brain cannabinoid receptors known to disrupt coordinated activity in hippocampus, to investigate the roles of network oscillations during hippocampal and medial prefrontal cortical (mPFC) interactions in rats. During quiet wakefulness and rest, CP55940 dose-dependently reduced 0.1-30 Hz local field potential power in CA1 of the hippocampus while concurrently decreasing 30 -100 Hz power in mPFC; these contrasting population-level effects were paralleled by differential effects on underlying single-unit activity in the two structures. During decision-making phases of a spatial working memory task, CP5540-induced deficits in hippocampal theta and prefrontal gamma oscillations were observed alongside disrupted theta-frequency coherence between the two structures. These changes in coordinated limbic-cortical network activities correlated with (1) reduced accuracy of task performance, (2) impaired phase-locking of prefrontal single-unit spiking to the local gamma and hippocampal theta rhythms, and (3) impaired task-dependent activity in a subset of mPFC units. In addition to highlighting the importance of CA1-mPFC network oscillations for cognition, these results implicate disrupted theta-frequency coordination of CA1-mPFC activity in the cognitive deficits caused by exogenous activation of brain cannabinoid receptors.

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“…By binding to CB1 receptors, which are located on GABAergic interneurons and widely distributed in the brain (Cohen et al 2008;Eggan and Lewis 2007), the cannabic constituent Δ-9-THC reduces GABA release, and hence attenuates the inhibitory effect, of these interneurons (Cohen et al 2008;Fernandez-Espejo et al 2009). Reduced GABAergic inhibition, in turn, leads to reduced synchrony of firing of groups of pyramidal neurons (Hajos et al 2008;Hajos et al 2000). Such synchrony is thought to be necessary for a variety of cognitive functions (Miltner et al 1999;Sarnthein et al 1998;Soltesz and Staley 2006;Varela et al 2001), and its demonstrated deficiency in schizophrenia has been proposed as an underlying cause of cognitive deficits and psychosis in this disorder (Benes and Berretta 2001;Ford et al 2007;Uhlhaas and Singer 2010).…”

Section: Introductionmentioning

confidence: 99%

Association of abnormal semantic processing with delusion-like ideation in frequent cannabis users: an electrophysiological study

et al. 2012

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Rationale-Frequent cannabis use is a risk marker for schizophrenia and delusions, but the neurocognitive mechanisms of this relationship remain unclear.Objectives-We sought evidence that cannabis users have deficits in processing relationships between meaningful stimuli, similar to abnormalities reported in schizophrenia, and that these deficits are associated with delusion-like ideation. We used the N400 event-related brain potential (ERP) waveform as a neurophysiological probe of activation of concepts in semantic memory. We hypothesized that cannabis users would exhibit larger (more negative) than normal N400 amplitudes in response to stimuli meaningfully related to a preceding prime-reflecting deficient activation of concepts related to the prime. We further hypothesized that the magnitude of this abnormality would correlate with severity of delusion-like ideation.Methods-We recorded ERPs in 24 frequent cannabis users and 24 non-using comparison participants who viewed prime words followed by targets which were either words related or unrelated to the prime or pronounceable non-words. The participants' task was to indicate whether the target was a word. Delusion-like ideation was measured via the Schizotypal Personality Questionnaire.Results-Contrary to our hypothesis, cannabis users exhibited smaller than normal N400s to both related and unrelated targets. These abnormalities correlated with delusion-like ideation in cannabis users only. Conclusions-The results are consistent with a generalized abnormality of activation within semantic memory neural networks in cannabis users. Further research is needed to investigate whether such an abnormality plays a role in the development of delusion-like ideation in cannabis users.

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Activation of Cannabinoid-1 Receptors Disrupts Sensory Gating and Neuronal Oscillation: Relevance to Schizophrenia

Cited by 149 publications

References 51 publications

Adolescent Cannabinoid Exposure Permanently Suppresses Cortical Oscillations in Adult Mice

Adolescent Cannabinoid Exposure Permanently Suppresses Cortical Oscillations in Adult Mice

Dysfunctional Prefrontal Cortical Network Activity and Interactions following Cannabinoid Receptor Activation

Association of abnormal semantic processing with delusion-like ideation in frequent cannabis users: an electrophysiological study

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