Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture

Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF

“…manifests anti-inflammatory (Ding et al, 2017), anti-oxidative Sutalangka et al, 2013), anti-apoptotic (Guo et al, 2015) and anti-Aβ effects Liu et al, 2017;Zhang M. et al, 2017) in AD. These effects meet the need for a multimodal AD therapy (Ubhi and Masliah, 2013;Ibrahim and Gabr, 2019).…”

Verum- versus Sham-Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta-Analysis

“…In the four rats models, intraperitoneal injection of scopolamine (SCO) was used to establish an AD model in one study [29] and intracerebroventricular (ICV) injection of Aβ 1-42 was used in two studies [34,35], and the ICV injection of Aβ 1-40 was used in the rest one study [38]. In mice models, three studies adopted APP/PS1 double transgenic mice model [28,33,39], and the rest used SAMP8 mice model as mentioned above [27,32,36,37,40].…”

“…e quality assessments of 12 included papers are illustrated in Tables 3 and 4, and the score of the study quality ranged from 2 to 8 out of a total 10 points. Among the 12 studies, only two studies described the specific random method [37,39]. Similarly, only two studies clearly showed that the baseline characteristics had been evaluated or adjusted among the groups before the intervention [35,39], and two studies reported that caregivers or investigators were blinded during the study [29,33], respectively.…”

“…Eleven studies [27][28][29][32][33][34][35][36][37][38][39] adopted escape latency as an outcome indicator, and all reported a positive effect of verum-acupuncture in reducing escape latency. However, there was a high heterogeneity among the studies (p < 0.00001, I 2 � 84%), and random effects model thereby was performed for analysis.…”

Electro-acupuncture Alleviates METH Withdrawal-induced Spatial Memory Deficits by Restoring Astrocyte-drived Glutamate Uptake in dCA1

“…For the EA treatments, two small acupuncture needles (0.25 × 13 mm, Hwato, China) were inserted gently in a depth of 2-3 mm to the acupoints at Baihui (GV 20, located in the midpoint between the auricular apices) and Yintang (GV29, located midway between the medial ends of the two eyebrows) 17 , stimulated with dilatational waves of 2/100 Hz at an intensity of 1-2 mA (causing the slight vibration of muscles around acupoints) with peak voltage of 9 V by the EA device 34 (HANS-100A, Nanjing Jisheng Medical Technology, China) for 30 min, once a day for 14 consecutive days. For the SEA treatments: all procedures were same as the METH + EA group, the only difference was the acupoints located at "placebo-point" (below the costal region, 2 cm superior to the posterior superior iliac spine and ~3 cm lateral to the spine) 35 .…”