2002
DOI: 10.1128/mcb.22.22.7831-7841.2002
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Abstract: Activation of Akt, or protein kinase B, is frequently observed in human cancers. Here we report that Akt activation via overexpression of a constitutively active form or via the loss of PTEN can overcome a G 2 /M cell cycle checkpoint that is induced by DNA damage. Activated Akt also alleviates the reduction in CDC2 activity and mitotic index upon exposure to DNA damage. In addition, we found that PTEN null embryonic stem (ES) cells transit faster from the G 2 /M to the G 1 phase of the cell cycle when compare… Show more

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Cited by 266 publications
(221 citation statements)
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“…Activation of Akt occurs in response to diverse noxious stimuli, including UV radiation, osmotic stress, and oxidative damage (Mockridge et al, 2000;Gao et al, 2002;Mildner et al, 2002). In the case of oxidative injury, Akt activation generally involves PTEN inactivation (Kandel et al, 2002), and results in attenuation of lethality (Persad et al, 2000). The present findings suggest that the relationship between 2ME-mediated oxidative injury and effects on Akt activity differ from those of previous reports.…”
Section: Me-induced Apoptosis In Human Leukemia Cells N Gao Et Al 2004)contrasting
confidence: 57%
“…Activation of Akt occurs in response to diverse noxious stimuli, including UV radiation, osmotic stress, and oxidative damage (Mockridge et al, 2000;Gao et al, 2002;Mildner et al, 2002). In the case of oxidative injury, Akt activation generally involves PTEN inactivation (Kandel et al, 2002), and results in attenuation of lethality (Persad et al, 2000). The present findings suggest that the relationship between 2ME-mediated oxidative injury and effects on Akt activity differ from those of previous reports.…”
Section: Me-induced Apoptosis In Human Leukemia Cells N Gao Et Al 2004)contrasting
confidence: 57%
“…Upon activation, mTOR phosphorylates its downstream targets, such as p70S6K, promoting cell survival through phosphorylation (inactivation) of the proapoptotic protein BAD (45). As has been previously shown in tumor cells, AKT expression is upregulated in concert with cyclin D expression (46)(47)(48) confirming the important role of AKT regulation in the cell cycle (49,50).…”
mentioning
confidence: 49%
“…The loss of PTEN is thought to play an important role in tumor cell proliferation and metastasis, due to a lack of control of the signaling pathways that mediate cellular processes such as apoptosis and migration (Huang and Kontos, 2002;Kandel et al, 2002;Pene et al, 2002). We stably PTEN is a dual-specificity phosphatase that can dephosphorylate lipid signaling molecules and proteins involved in tyrosine kinase receptor signaling cascades (Dupont et al, 2001;Yamada and Araki, 2001;Fernandez and Eng, 2002).…”
Section: Discussionmentioning
confidence: 99%