J. Neurosci. Res. volume 86, issue 13, P2820-2828 2008 DOI: 10.1002/jnr.21742 View full text
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Hideyuki Migita, Katsuya Kominami, Mami Higashida, Rumi Maruyama, Nobuko Tuchida, Fiona McDonald, Fumiki Shimada, Kazuhiro Sakurada

Abstract: Adenosine, a modulator of neuronal function in the mammalian central nervous system, exerts a neuroprotective effect via the adenosine A(1) receptor; however, its effect on neural stem cells (NSCs) remains unclear. Because adenosine is released in response to pathological conditions and NSCs play a key role in neuroregeneration, we tested the hypothesis that adenosine is capable of stimulating NSC proliferation. We demonstrated that NSCs dominantly express adenosine A(1) and A(2B) receptors. Adenosine and the …

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