2019
DOI: 10.1186/s13045-019-0721-x
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Abstract: During tumor progression, a subset of cancer cells escape from immune surveillance and eventually develop into measurable tumor mass. Cancer immunotherapy eradicates tumor cells by enhancing multiple steps in cancer-immunity cycle including antigen presentation, T cell priming, activation, and immune killing activity. Immunotherapy has been verified as an effective strategy in multiple cancers, but some problems still exist in actual clinical practice such as frequent primary and adaptive resistance. Combinati… Show more

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Cited by 219 publications
(185 citation statements)
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References 114 publications
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“…The muted T cell response we observed in the absence of cGAS was analogous to the findings in the anti-tumor response, where cGAS-STING activation was required for the recruitment of tumor specific CD8+ T cells and their infiltration into the tumor environment (Harding et al, 2017;Ohkuri et al, 2014;Wang et al, 2017). These effects were largely attributed to the IFN-I response gene CXCL10, a recognized CD8+ T cell chemoattractant (Christensen et al, 2006;Li et al, 2019;Liu et al, 2015). Indeed, we found decreased CXCL10 expression in the skin of cGAS-deficient mice both early and 24hr after exposure to UVB (Fig.…”
Section: Absence Of Cgas Dampens the Cellular Inflammatory Response Isupporting
confidence: 73%
“…The muted T cell response we observed in the absence of cGAS was analogous to the findings in the anti-tumor response, where cGAS-STING activation was required for the recruitment of tumor specific CD8+ T cells and their infiltration into the tumor environment (Harding et al, 2017;Ohkuri et al, 2014;Wang et al, 2017). These effects were largely attributed to the IFN-I response gene CXCL10, a recognized CD8+ T cell chemoattractant (Christensen et al, 2006;Li et al, 2019;Liu et al, 2015). Indeed, we found decreased CXCL10 expression in the skin of cGAS-deficient mice both early and 24hr after exposure to UVB (Fig.…”
Section: Absence Of Cgas Dampens the Cellular Inflammatory Response Isupporting
confidence: 73%
“…In addition to these, tumor-derived DNA has been demonstrated to induce IFN-β production via cGAS-STING-IRF3 axis, contributing to spontaneous T cell-and natural killer cell mediated-anti-tumor responses. STING-deficient mice and IRF3-deficient mice exhibited defective tumor rejection (117)(118)(119). Several innate immune receptor ligands, such as poly (I:C), LPS and CpG, were proven to be efficient antitumor agents in different models of cancer [review in (120)].…”
Section: Perspectives Of Hippo-yap -Innate Immunity Crosstalk In Tumomentioning
confidence: 99%
“…However, as a cascade reaction, the actual effect of immunotherapy is limited by its upstream or downstream factors such as systemic cytokine repertoire, the cross-presentation of antigen presentation cell, as well as the inhibitory components in the tumor immune microenvironment. 107 Gut microbiota could regulate a broad range of immune effectors, especially DC. As the core of antigen presentation and T cell activation, the function of DC is the determinant of immune surveillance and immune clearance.…”
Section: Putative Mechanisms By Which the Gut Microbiota May Regulatementioning
confidence: 99%