Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system

McCormick, David A.; Pape, Hans‐Christian; Williamson, Anne

doi:10.1016/s0079-6123(08)63817-0

Cited by 195 publications

(135 citation statements)

References 52 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…Flx acutely inhibits neuronal reuptake of serotonin, and this monoamine is able to potentiate the action of excitatory stimuli on cortical pyramidal neurons, for example, through inhibition of Ca-activated K channels (Aghajanian, 1995;Ansanay et al, 1995;Araneda and Andrade, 1991;Foehring et al, 2002;Goaillard and Vincent, 2002;Torres et al, 1995;Wallén et al, 1989) or inhibition of voltage-activated K channels (Aghajanian, 1995;Andrade and Nicoll, 1987;Beck, 1992). Similar proexcitatory effects have been also described for norepinephrine (Larkman and Kelly, 1992;Lee and McCormick, 1996;Madison and Nicoll, 1986a, b;McCormick et al, 1991). Increased serotonin or norepinephrine in the synaptic cleft could thus induce a moderate neuronal excitation and, as a consequence, an increase in BDNF synthesis and release.…”

Section: Decrease Of Trkb In Psdsmentioning

confidence: 74%

Clinically Relevant Doses of Fluoxetine and Reboxetine Induce Changes in the TrkB Content of Central Excitatory Synapses

Wyneken

Sandoval

et al. 2006

Neuropsychopharmacol

View full text Add to dashboard Cite

We have studied the effect of low doses of two widely used antidepressants, fluoxetine (Flx) and reboxetine (Rbx), on excitatory synapses of rat brain cortex and hippocampus. After 15 days of Flx treatment (0.67 mg/kg/day), its plasma level was 20.775.6 ng/ml. Analysis of postsynaptic densities (PSDs) by immunoblotting revealed no changes in the glutamate receptor subunits GluR1, NR1, NR2A/ B, mGluR1a nor in the neurotrophin receptor p75 NTR . However, the brain-derived neurotrophic factor (BDNF) receptor TrkB decreased by 42.876%, and remained decreased after 6 weeks of treatment. The BDNF and TrkB content in homogenates of cortex and hippocampus began to rise at 9 and 15 days, respectively, and remained high for up to 6 weeks. Similar results were obtained following chronic Rbx administration at 0.128 mg/kg/day. We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs. This was paralleled by greater levels of phosphorylated (ie activated) TrkB in the light membrane fraction, that contains signaling endosomes. The retrograde transport of endocyted BDNF/TrkB complexes from spines to cell bodies, where it activates the synthesis of more BDNF, is a protracted process, potentially requiring several cycles of TrkB/BDNF complex endocytosis and transport. This positive feedback mechanism may help explain the time-lag between drug administration and its therapeutic effect, that is, the antidepressant drug paradox.

show abstract

Section: Decrease Of Trkb In Psdsmentioning

confidence: 74%

Clinically Relevant Doses of Fluoxetine and Reboxetine Induce Changes in the TrkB Content of Central Excitatory Synapses

Wyneken

Sandoval

et al. 2006

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Methamphetamine on histamine-deficient mice 841 neuron systems are critically implicated in the regulation of the sleep-wake cycle (McCormick et al 1991;Crochet and Sakai 1999;Kohlmeier and Reiner 1999). Cirelli and Tononi (1998) reported that the positively stained neurons with anti-PSER are more abundant in the brain of a wakeful rat than in that of a sleeping rat, and this change is controlled by the stimulation of locus coeruleus in which the NA neurons are rich.…”

Section: Discussionmentioning

confidence: 99%

Increased methamphetamine‐induced locomotor activity and behavioral sensitization in histamine‐deficient mice

Kubota

Ito²,

Sakurai

et al. 2002

Journal of Neurochemistry

View full text Add to dashboard Cite

We have recently suggested that the brain histamine has an inhibitory role on the behavioral effects of methamphetamine by pharmacological studies. In this study, we used the histidine decarboxylase gene knockout mice and measured the spontaneous locomotor activity, the changes of locomotion by single and repeated administrations of methamphetamine, and the contents of brain monoamines and amino acids at 1 h after a single administration of methamphetamine. In the histidine decarboxylase gene knockout mice, spontaneous locomotor activity during the dark period was significantly lower than in the wild-type mice. Interestingly, methamphetamine-induced locomotor hyperactivity and behavioral sensitization were facilitated more in the histidine decarboxylase gene knockout mice. In the neurochemical study, noradrenaline and O-phosphoserine were decreased in the midbrain of the saline-treated histidine decarboxylase gene knockout mice. On the other hand, single administration of methamphetamine decreased GABA content of the midbrain of the wild-type mice, but did not alter that of histidine decarboxylase gene knockout mice. These results suggest that the histamine neuron system plays a role as an awakening amine in concert with the noradrenaline neuron system, whereas it has an inhibitory role on the behavioral effects of methamphetamine through the interaction with the GABAergic neuron system.

show abstract

“…This is counter to one report in which spindles in human frontal and parietal cortex decreased in frequency from onset to offset (Andrillon et al, 2011). Andrillon et al (2011) proposed that this might indicate increasing thalamic hyperpolarization altering the latency of Ca 2ϩ spike bursts in TC cells over the course of spindles (McCormick and Bal, 1997). Species or recording (particularly the use of iEEG as opposed to LFP) differences may contribute to the discrepancy between our findings, although our results showing intraspindle acceleration are consistent with the hypothesis that the depolarizing I h current in TC cells is upregulated during the late phase of spindles (Bal and McCormick, 1996).…”

Section: Spectral Dynamics Of Mpfc Spindles and Effects On Thalamocormentioning

confidence: 99%

“…One possible influence on the temporal activation patterns of early-and late-firing Py and NS cells is the locus ceruleus (LC), which has diffuse norepinephrinergic projections into the cortex that are believed to strongly modulate cell excitability (McCormick et al, 1991). The firing of LC neurons is phase-locked to cycles of slow oscillation (Eschenko et al, 2012) and these neurons also show elevated firing during spindles (Aston-Jones and Bloom, 1981).…”

Section: Structured Activity Of Cortical Subnetwork During Spindlesmentioning

confidence: 99%

Differential Spike Timing and Phase Dynamics of Reticular Thalamic and Prefrontal Cortical Neuronal Populations during Sleep Spindles

2013

View full text Add to dashboard Cite

The 8 -15 Hz thalamocortical oscillations known as sleep spindles are a universal feature of mammalian non-REM sleep, during which they are presumed to shape activity-dependent plasticity in neocortical networks. The cortex is hypothesized to contribute to initiation and termination of spindles, but the mechanisms by which it implements these roles are unknown. We used dual-site local field potential and multiple single-unit recordings in the thalamic reticular nucleus (TRN) and medial prefrontal cortex (mPFC) of freely behaving rats at rest to investigate thalamocortical network dynamics during natural sleep spindles. During each spindle epoch, oscillatory activity in mPFC and TRN increased in frequency from onset to offset, accompanied by a consistent phase precession of TRN spike times relative to the cortical oscillation. In mPFC, the firing probability of putative pyramidal cells was highest at spindle initiation and termination times. We thus identified "early" and "late" cell subpopulations and found that they had distinct properties: early cells generally fired in synchrony with TRN spikes, whereas late cells fired in antiphase to TRN activity and also had higher firing rates than early cells. The accelerating and highly structured temporal pattern of thalamocortical network activity over the course of spindles therefore reflects the engagement of distinct subnetworks at specific times across spindle epochs. We propose that early cortical cells serve a synchronizing role in the initiation and propagation of spindle activity, whereas the subsequent recruitment of late cells actively antagonizes the thalamic spindle generator by providing asynchronous feedback.

show abstract

Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system

Cited by 195 publications

References 52 publications

Clinically Relevant Doses of Fluoxetine and Reboxetine Induce Changes in the TrkB Content of Central Excitatory Synapses

Clinically Relevant Doses of Fluoxetine and Reboxetine Induce Changes in the TrkB Content of Central Excitatory Synapses

Increased methamphetamine‐induced locomotor activity and behavioral sensitization in histamine‐deficient mice

Differential Spike Timing and Phase Dynamics of Reticular Thalamic and Prefrontal Cortical Neuronal Populations during Sleep Spindles

Contact Info

Product

Resources

About