Action of meningococcal lipopolysaccharide on platelet function

Pokrovskiĭ, V I; Bulychev, V. V.; Lomazova, Kh. D.; Gracheva, A M; Polyakova, A. M.; Buryachkovskaya, L. I.; Mol'kov, N. Yu.

doi:10.1007/bf00833985

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2006

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“…Platelets are one of the main cell objects of the primary pathogenic effect of LPS [3]. Evaluation of the effect of polysaccharide on parameters of hemostasis showed that κ-carrageenan in a concentration of 100 µg/ml inhibited (by 3.48 times) spontaneous platelet aggregation, prolonged (by 3.05 times) activated partial thromboplastin time, prothrombin time (by 1.4 times), and thrombin time (by 1.49 times) and significantly stimulated activity of AT-III (by 7.88 times), a potent natural inhibitor of clotting, in comparison with samples without carrageenan.…”

Section: Resultsmentioning

confidence: 99%

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Natural polysaccharide carrageenan inhibits toxic effect of gram-negative bacterial endotoxins

et al. 2006

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The protective effect of polysaccharide carrageenan on the damaging effect of endotoxins of gram-negative bacteria was studied in vivo and in vitro. Carrageenan increased mouse resistance to the toxic effect of LPS. The degree of protection depended on polysaccharide concentration and administration time and route. Pretreatment of donor platelets with carrageenan reduced their aggregation activity caused by cooperative effect of LPS and ADP.

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Section: Resultsmentioning

confidence: 99%

“…In vitro experiments on evaluation of donor platelet aggregation under the effects of LPS and carrageenans were carried out as described previously [3]. Platelet aggregation activity was studied using standard ADP inductor (2×10 -5 M) on an AP-2110 aggregometer (SOLAR).…”

Section: Methodsmentioning

confidence: 99%