Action of FGMgCO3Ap-collagen composite in promoting bone formation

Yamasaki, Yasundo; Yoshida, Yasuhiro; Okazaki, Masanori; Shimazu, Atsushi; Kubo, Toru; Akagawa, Yasumasa; Uchida, Tatsuhiko

doi:10.1016/s0142-9612(03)00414-9

Cited by 166 publications

(90 citation statements)

References 22 publications

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“…The biologically inspired biocomposites of collagen and calcium orthophosphates (mainly, apatites) for bone substitute have a long history [29,364,499,[597][598][599][600][601][602][603][604][605][606][607][608][609][610][611][612][613][614][615] and started from the pioneering study by Mittelmeier and Nizard [616], who mixed calcium orthophosphate granules with a collagen web. Such combinations were found to be bioactive, osteoconductive, osteoinductive [29,585,[617][618][619] and, in general, artificial grafts manufactured from this type of the biocomposites are likely to behave similarly to bones and be of more use in surgery than those prepared from any other materials. Indeed, some data are available on the superiority of calcium orthophosphate/collagen biocomposite scaffolds over the artificial polymeric and calcium orthophosphate bioceramic scaffolds individually [620].…”

Section: Biocomposites With Collagenmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

283

146

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Section: Biocomposites With Collagenmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

283

146

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“…These endothelial cells are important in new blood vessels formation, which in turn is important for providing essential nutrients to newly forming bone cells. Additionally, magnesium has been shown to improve the osteogenic differentiation of cells, and indirectly, bone formation [16,17]. Moreover, our previous results showed that 50 wt% MCP gelatin sponges have improved mesenchymal cellular proliferation and alkaline phosphatase activity in comparison with the 0 wt% gelatin sponges and improved osteocalcin activity in comparison with the 90 wt% MCP gelatin sponges.…”

Section: Discussionmentioning

confidence: 96%

Bone Regeneration of Rat Calvarial Defect by Magnesium Calcium Phosphate Gelatin Scaffolds with or without Bone Morphogenetic Protein-2

Hussain

Takahashi

Sonobe

et al. 2013

J. Maxillofac. Oral Surg.

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Regeneration of large bone losses has been achieved with limited success due to either donor site complications in autogenous bone graft or lack of an ideal biomaterial in the case of allografts. Magnesium calcium phosphate-gelatin sponges were prepared with different concentrations of MCP; namely 0, 50 and 90 wt%. Eight mm defects were drilled in the calvaria of 48 male Fischer 344 rats. MCP-gelatin scaffolds containing or without bone morphogenetic protein were placed at the defect site. Animals were sacrificed at 3 and 12 weeks, post-operatively, with evaluation of bone regeneration by using micro CT and histological examinations. Results showed that the combination of BMP-2 and gelatin sponges could provide a slow release system that significantly enhanced bone regeneration at both 3 and 12 weeks in comparison with the non BMP-2-containing 90 wt% MCP-gelatin sponges. The combination of 50 wt% MCP-gelatin sponges and BMP-2 showed significant bone formation at 3 weeks in comparison with the non BMP-2 containing gelatin sponges, indicating that the addition of MCP to the gelatin scaffold had a synergistic advantage in combination with BMP-2. This novel scaffold has shown adequate porosity to allow cell growth, amenability for sterilization, biocompatibility and biodegradability with the ability to provide a slow release system for BMP-2 to enhance bone regeneration.

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“…Other authors refer that the release of magnesium ions does not cause local or systemic toxicity, and may have beneficial effects on the cellular response in areas where they are located [29]. Moreover, the magnesium added to calcium phosphate cements improves the adhesion of osteoblasts, it is suggested that the binding of cells to biomaterials plays an important role in the rapid restoration of the defective area [30].…”

Section: Discussionmentioning

confidence: 99%

“…After 30 min, they were rinsed again and kept in PBS at 4 ºC. After cell fixation, the specimens were dehydrated in ethanol solutions of varying concentration (15,30,50,70,90, and 100 %) for about 30 min at each concentration. The specimens were then dried, using the critical-point dry technique, and subsequently they were coated with carbon using the evaporator Balzers MED-010 (Balzers Union, Liechtenstein), and then coated with gold using metallization K550X…”

Section: Cell Morphologymentioning

confidence: 99%

Magnesium substitution in brushite cements for enhanced bone tissue regeneration

Cabrejos-Azama

Alkhraisat

Rueda

et al. 2014

Materials Science and Engineering: C

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We have synthesized calcium phosphate cements doped with different amounts of magnesium (Mg-CPC) with a twofold purpose: i) to evaluate in vitro the osteoblast cell response to this material, and ii) to compare the bone regeneration capacity of the doped material with a calcium cement prepared without magnesium (CPC). Cell proliferation and in vivo response increased in the Mg-CPCs in comparison with CPC. The Mg-CPCs have promoted higher new bone formation than the CPC (p < 0.05). The cytocompatibility and histomorfometric analysis performed in the rabbit calvaria showed that the incorporation of magnesium ions in CPC improves osteoblasts proliferation and provides higher new bone formation. The development of a bone substitute with controllable biodegradable properties and improved bone regeneration can be considered a step towards personalized therapy that can adapt to patient needs and clinical situations.

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Action of FGMgCO3Ap-collagen composite in promoting bone formation

Cited by 166 publications

References 22 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Bone Regeneration of Rat Calvarial Defect by Magnesium Calcium Phosphate Gelatin Scaffolds with or without Bone Morphogenetic Protein-2

Magnesium substitution in brushite cements for enhanced bone tissue regeneration

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