Action of Cortisone on Mesenchymal Tissues

The Effects of Adrenocortical Hormones on Albumin Metabolism Studied with Albumin-I1311

“…Although an increased loss of urinary nitrogen frequently accompanies the administration of excess adrenocortical hormones (4,6,(13)(14)(15)(16)(17), it has been emphasized that such excretory data only reflect the overall picture (17), for while some tissues are particularly susceptible to the wasting action of these hormones (18)(19)(20)(21)(22)(23), others such as the liver, gastrointestinal tract and urogenital organs may actually show a positive nitrogen balance (13,15,17). The present studies indicate that serum albumin metabolism is significantly altered during the administration of certain adrenocortical hormones.…”

Diseases of Bones and Joints

“…Blood studies in their animals showed a marked rise in a-globulin fraction and a less marked fall in the 'Y-globulin while under medication with cortisone. Plotz et al (195) noted the inhibition of the formation of granulation tissue in wounds of the rabbit ear and sug gested that the beneficial action of cortisone and ACTH in mesenchymal diseases might be related to the depressive effect on host reactivity. Spain et at.…”