Action of Alkalies on the Corneal Stroma roma

Decellularized Cartilage Matrix as a Novel Biomatrix for Cartilage Tissue-Engineering Applications

“…46 The degree of denaturation caused by NaOH treatment depends on the applied concentration of NaOH solution and time of exposure. [47][48][49] Hydroxide ions form ionic and nonionic bonding to collagen and induce tissue swelling, as well as lyotropic effects, and subsequently, the hydrolysis of collagen due to the breakdown of intermolecular bonding and release of further hydroxide ions. 48 Applied chaotropic salt and hydrogen peroxide solutions have an inconsiderable influence on the amount of denatured collagen, as own unpublished examinations have shown.…”

Decellularized Cartilage Matrix as a Novel Biomatrix for Cartilage Tissue-Engineering Applications

“…46 The degree of denaturation caused by NaOH treatment depends on the applied concentration of NaOH solution and time of exposure. [47][48][49] Hydroxide ions form ionic and nonionic bonding to collagen and induce tissue swelling, as well as lyotropic effects, and subsequently, the hydrolysis of collagen due to the breakdown of intermolecular bonding and release of further hydroxide ions. 48 Applied chaotropic salt and hydrogen peroxide solutions have an inconsiderable influence on the amount of denatured collagen, as own unpublished examinations have shown.…”

Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium

“…20,21 Many patients in this series had washed their eyes at home, before attending the ophthalmologist's clinic for first aid; despite this, all these patients developed severe surface damage.…”

Early and Intensive Management of Chemical Eye Injuries: Case Series

“…The damaged tissue secrete proteolytic enzymes as part of an inflammatory response which leads to further damage. Alkali substances can penetrate into the anterior chamber causing cataract formation, damage to the ciliary body and damage to the trabecular meshwork" [1,5].…”

“…"The next steps in management focus on closing the epithelium, controlling inflammation, and supporting corneal repair" [5,15]. "Treatment should be based on the initial estimate of the extent of limbal stem cell injury.…”

Decellularized Cartilage Matrix as a Novel Biomatrix for Cartilage Tissue-Engineering Applications

“…46 The degree of denaturation caused by NaOH treatment depends on the applied concentration of NaOH solution and time of exposure. [47][48][49] Hydroxide ions form ionic and nonionic bonding to collagen and induce tissue swelling, as well as lyotropic effects, and subsequently, the hydrolysis of collagen due to the breakdown of intermolecular bonding and release of further hydroxide ions. 48 Applied chaotropic salt and hydrogen peroxide solutions have an inconsiderable influence on the amount of denatured collagen, as own unpublished examinations have shown.…”

Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium

“…20,21 Many patients in this series had washed their eyes at home, before attending the ophthalmologist's clinic for first aid; despite this, all these patients developed severe surface damage.…”

Early and Intensive Management of Chemical Eye Injuries: Case Series

“…The damaged tissue secrete proteolytic enzymes as part of an inflammatory response which leads to further damage. Alkali substances can penetrate into the anterior chamber causing cataract formation, damage to the ciliary body and damage to the trabecular meshwork" [1,5].…”

“…"The next steps in management focus on closing the epithelium, controlling inflammation, and supporting corneal repair" [5,15]. "Treatment should be based on the initial estimate of the extent of limbal stem cell injury.…”

Decellularized Cartilage Matrix as a Novel Biomatrix for Cartilage Tissue-Engineering Applications

“…46 The degree of denaturation caused by NaOH treatment depends on the applied concentration of NaOH solution and time of exposure. [47][48][49] Hydroxide ions form ionic and nonionic bonding to collagen and induce tissue swelling, as well as lyotropic effects, and subsequently, the hydrolysis of collagen due to the breakdown of intermolecular bonding and release of further hydroxide ions. 48 Applied chaotropic salt and hydrogen peroxide solutions have an inconsiderable influence on the amount of denatured collagen, as own unpublished examinations have shown.…”

Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium

“…20,21 Many patients in this series had washed their eyes at home, before attending the ophthalmologist's clinic for first aid; despite this, all these patients developed severe surface damage.…”

Early and Intensive Management of Chemical Eye Injuries: Case Series

“…The damaged tissue secrete proteolytic enzymes as part of an inflammatory response which leads to further damage. Alkali substances can penetrate into the anterior chamber causing cataract formation, damage to the ciliary body and damage to the trabecular meshwork" [1,5].…”

“…"The next steps in management focus on closing the epithelium, controlling inflammation, and supporting corneal repair" [5,15]. "Treatment should be based on the initial estimate of the extent of limbal stem cell injury.…”