Actinomycosis of tongue: Rare presentation mimicking malignancy with literature review and imaging features

Ahmed, Siddiq; Ali, Muhammad; Adegbite, Nurudeen; Vaidhyanath, Ram; Avery, C.M.E.

doi:10.1016/j.radcr.2018.10.022

Cited by 12 publications

(12 citation statements)

References 18 publications

(10 reference statements)

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“…Nevertheless, in our case, the TPHA (Treponema Pallidum Hemoagglutination Assay) was negative at admission in the hospital [ 60 , 61 ]. Tuberculosis causes ulcerations as well, affecting mainly the tongue and the palate, and usually have an “infiltrating” feature more than exophytic [ 62 ]; furthermore, pathology can reveal typical caseous tuberculous granulomas which can drive the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Saprochaete clavata Infection in Immunosuppressed Patients: Systematic Review of Cases and Report of the First Oral Manifestation, Focusing on Differential Diagnosis

Lajolo

Rupe

Schiavelli

et al. 2021

IJERPH

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Background: Saprochaete clavata infection is an emerging issue in immunosuppressed patients, causing fulminant fungaemia. The purpose of this systematic review of cases is to retrieve all cases of S. clavata infection and describe oral lesions as the first manifestation of S. clavata infection. Methods: We report the first case of intraoral S. clavata infection in Acute Myeloid Leukemia (AML) affected subject, presenting as multiple grayish rapidly growing ulcerated swellings, and provide a review of all published cases of infection caused by S. clavata, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, conducted by searching SCOPUS, Medline, and CENTRAL databases. Only articles in English were considered. Individual patient data were analyzed to identify risk factors for S. clavata infection. Results: Seventeen of 68 retrieved articles were included in the review reporting data on 96 patients (mean age 51.8 years, 57 males and 38 females). Most cases were disseminated (86) with a 60.2% mortality rate. Ninety-five were hematological patients, with AML being the most common (57 cases). Conclusions:S. clavata infection in immunosuppressed patients has a poor prognosis: middle-age patients, male gender and Acute Myeloid Leukemia should be considered risk factors. In immunosuppressed patients, the clinical presentation can be particularly unusual, imposing difficult differential diagnosis, as in the reported case.

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Section: Discussionmentioning

confidence: 99%

Saprochaete clavata Infection in Immunosuppressed Patients: Systematic Review of Cases and Report of the First Oral Manifestation, Focusing on Differential Diagnosis

Lajolo

Rupe

Schiavelli

et al. 2021

IJERPH

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“…Both children had polymicrobial infection, which is commonly present in actinomycosis and can make diagnosis more challanging. 11 Actinomycosis is rare in childhood but more common in middle aged individuals. It can mimic a wide variety of diseases, including malignancy and tuberculosis and presents with an array of symptoms making diagnosis challenging.…”

Section: Discussionmentioning

confidence: 99%

Cervicofacial Actinomycosis in the Pediatric Population: Presentation and Management

Gandhi

Woerd

Graham

et al. 2021

Ann Otol Rhinol Laryngol

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Background: Infection caused by Actinomyces species is a rare cause of head and neck infection in children. This chronic cervicofacial infection can present with localized swelling, abscess formation, sinus drainage and can be complicated by osteomyelitis. Methods: Presented are 2 pediatric cases of secondary actinomycosis in the context of congenital lesions: 1 patient with a previously excised preauricular sinus and another with a persistent sublingual mass. A comprehensive literature search was conducted for reported cases of pediatric actinomycosis in the cervicofacial region. Results: Both cases presented were successfully treated with a combination of complete surgical excision of the lesions and prolonged antibiotic therapy. Thirty-four pediatric cases of cervicofacial actinomycosis are reviewed, 2 presented herein, and 32 from the published literature. There was equal gender distribution and the median age was 7.5 years. The most common site for infection was the submandibular area. Four (12%) of cases arose in pre-existing congenital lesions. Most patients were treated with penicillin-based antibiotics for a median duration of 6 months following surgical excision or debridement. Conclusions: Actinomycosis is a rare infection of the cervicofacial region; secondary infections arising from congenital lesions of the head and neck are even more rare. A previously excised pre-auricular sinus and a sublingual dermoid cyst are not previously reported sites of infection. Actinomycosis should be suspected in chronically draining sinuses of the head and neck region and confirmed through anaerobic culture. Osteomyelitis is a potential complication and magnetic resonance (MR) imaging is warranted. Long-term antibiotic therapy with a penicillin-based antibiotic and surgical excision should be considered.

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“…Lingual actinomycosis is rare. In Table 1, case reports/series available from the literature are reviewed, with particular attention to patient management [4,6,[18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Actinomycosis of the Tongue: A Case Report and Review of Literature

et al. 2020

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Background: Actinomycosis of the tongue is an uncommon, suppurative infection of lingual mucosa, caused by actinomyces. The clinical diagnosis may present serious difficulties because of its ability to mimic other lesions, including both benign and malignant neoplasms. Methods: Here, we describe the case of a 52-years-old patient affected by an asymptomatic, tumor-like tongue swelling, then diagnosed as actinomycosis. A review of tongue localization of actinomycosis is also reported, with emphasis on clinical findings and therapy. Results and Conclusion: Early diagnosis and treatment, with pus drainage and systemic antibiotic therapy, are pivotal to avoid severe and life-threatening complications.

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Actinomycosis of tongue: Rare presentation mimicking malignancy with literature review and imaging features

Cited by 12 publications

References 18 publications

Saprochaete clavata Infection in Immunosuppressed Patients: Systematic Review of Cases and Report of the First Oral Manifestation, Focusing on Differential Diagnosis

Saprochaete clavata Infection in Immunosuppressed Patients: Systematic Review of Cases and Report of the First Oral Manifestation, Focusing on Differential Diagnosis

Cervicofacial Actinomycosis in the Pediatric Population: Presentation and Management

Actinomycosis of the Tongue: A Case Report and Review of Literature

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