Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain

Rodríguez-Blanco, Isabel; Flórez, Ángeles; Paredes-Suárez, Carmen; Rodríguez-Lojo, Romina; González‐Vilas, D.; Ramírez-Santos, A.; Paradela, Sabela; Conde, Ignacio Suárez; Pereiro-Ferreirós, M.M.

doi:10.2340/00015555-3014

Cited by 35 publications

(50 citation statements)

References 19 publications

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“…After title/abstract screening, 4324 papers were selected for abstract evaluation. Of these, 92 studies were included in the final analysis . Fourty‐six reports were on LP, 5 on OLL, 28 on LE, 8 on OE, 4 on OSF, and 11 on PVL (all the studies taken for every subgroup sum up to a figure higher than 92 because some studies focused on more than one OPMD).…”

Section: Resultsmentioning

confidence: 99%

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype

et al. 2019

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Importance: Potentially malignant disorders of the oral cavity (OPMD) are a heterogeneous group of lesions associated with a variable risk of malignant transformation (MT) to invasive cancer. Leukoplakia (LE), lichen planus (LP), oral lichenoid lesions (OLL), oral erythroplakia (OE), oral submucous fibrosis (OSF), and proliferative verrucous leukoplakia (PVL) are among the most common of these lesions. Oral dysplasia is a mucosal area characterized by cellular and architectural derangement, which may be associated with OPMDs or not. Objective: To define the MT rate of OPMDs and the risk of development into cancer of mild vs moderate/severe oral dysplasia. This in order to implement adequate follow-up strategies and treatment decisions. Study design:We performed a systematic review and meta-analysis on studies reporting the MT rates of OPMDs and oral dysplasia. Ninety-two studies were included for the analysis. Cumulative rates were reported for OPMDs overall and as a subgroup, a comparison was made of mild vs moderate/severe dysplasia. Meta-regression on OPMD and year of publication was also performed.Main outcome and measures: Overall MT rates of OPMDs and odds ratio of MT of mild vs moderate/severe dysplasia.

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Section: Resultsmentioning

confidence: 99%

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype

et al. 2019

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“…Consecutive patients, ≥ 45 years of age, attending a general dermatology outpatient clinic were recruited once a week. AC was defined by the presence of one or several of the following items (modified from Ribeiro et al [12]): persistent desquamation, persistent erythema, mottled appearance (erythema and white patches), plaques (solid, raised, flat lesion > 1 cm), and/or erosion/ulceration that could not be attributed to other dermatological disorders [11]. Demographic and medical variables investigated for correlation with lip photoprotection were sex, age, previous history of skin cancer, working outdoors, and Fiztpatrick's phototype.…”

Section: Methodsmentioning

confidence: 99%

“…Little attention has been paid in the past to sun protection habits focused on the lips and only few studies have investigated this issue. An epidemiological study was previously conducted by our group to determine the prevalence of AC and its associated variables [11]; lip photoprotection was specifically investigated in the subpopulation suffering from AC as well as its possible associations with demographic or clinical variables and sun exposure habits.…”

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confidence: 99%

Use of lip photoprotection in patients suffering from actinic cheilitis

Rodríguez-Blanco¹,

Flórez²,

Paredes-Suárez³

et al. 2019

European Journal of Dermatology

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Use of lip photoprotection in patients suffering from actinic cheilitisBackground: Actinic cheilitis (AC) is a chronic condition that affects mainly the lower lip. Objectives: To investigate the use of lip photoprotection in patients with AC. Materials and Methods: A cross-sectional multicentre study of patients, ≥45 years of age, was performed in eight dermatology departments in the Galicia region over a period of one year. From 1,239 patients included in the study, 410 were diagnosed with AC and complete data were available for 408. An analysis of lip photoprotection habits and possible associations in patients with AC is reported. Results: Mean age of patients with AC was 71.9 years and 53.8% were women. More than 90% of AC patients (370/408) had never used lip photoprotection. In the group of patients who used it, 62.16% of them had only used a single stick within the previous year. The only variable significantly associated with the use of lip sun protection was low Fitzpatrick's skin types I and II (p=0.039). Study limitations include the inclusion of patients 45 years or older and the use of a semiquantitative scale for measuring the frequency of application of lip photoprotection. Conclusion: To our knowledge, this is the first European study focused on lip photoprotection in patients suffering from AC. Only a minority of AC patients protect their lips from UV radiation. Specific lip sun protection recommendations should be promoted, especially in high-risk populations.

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“…Consecutive patients aged ≥45 years that attended a general dermatology outpatient clinic were recruited once a week. A physical examination of each patient was performed visually with or without a magnifying glass (2). Clinical characteristics of AC were precisely specified in a previous meeting attended by all the investigators to minimize inter-observer bias; characteristics were classified as follows: persistent desquamation, persistent erythema, a mottled appearance (erythema and white patches), and a plaque (solid, raised, flat lesion >1 cm) and/ or an erosion/ulceration that could not be attributed to other dermatological disorders (modified from Ribeiro et al) (3).…”

Section: Methodsmentioning

confidence: 99%

“…AC is considered a precursor of malignancy (1), but the rate of progression from AC to invasive squamous cell carcinoma (SCC) has not yet been established. An epidemiological study previously described the prevalence of AC and its associated variables in the Galicia region (north-western Spain); the prevalence of AC in a population aged 45 years and over was 31.3%, and multivariate analysis showed that significant and independent risk factors for AC were age ≥ 60 years, Fitzpatrick skin phototypes I and II, working outdoors for more than 25 years, and a history of non-melanoma skin cancer (NMSC) (2). We report here a subanalysis of the clinical manifestations of AC and the associations of AC with other markers of actinic damage.…”

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confidence: 99%

Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage

Rodríguez-Blanco

Flórez²,

Paredes-Suárez³

et al. 2019

Acta Derm Venerol

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Actinic cheilitis (AC) is a common condition that mainly involves the lower lip, which is associated with chronic exposure to ultraviolet (UV) radiation. AC is considered a precursor of malignancy (1), but the rate of progression from AC to invasive squamous cell carcinoma (SCC) has not yet been established. An epidemiological study previously described the prevalence of AC and its associated variables in the Galicia region (north-western Spain); the prevalence of AC in a population aged 45 years and over was 31.3%, and multivariate analysis showed that significant and independent risk factors for AC were age ≥ 60 years, Fitzpatrick skin phototypes I and II, working outdoors for more than 25 years, and a history of non-melanoma skin cancer (NMSC) (2). We report here a subanalysis of the clinical manifestations of AC and the associations of AC with other markers of actinic damage. METHODSA cross-sectional multicentre study was conducted in Galicia (the total population in 2016 was 2,718,525, data from Galician Statistics Institute; http://www.ige.eu), a region located in northwestern Spain. Eight dermatology departments participated in the study, and patient data were collected prospectively from 12 January 2016 to 31 January 2017. Consecutive patients aged ≥45 years that attended a general dermatology outpatient clinic were recruited once a week. A physical examination of each patient was performed visually with or without a magnifying glass (2). Clinical characteristics of AC were precisely specified in a previous meeting attended by all the investigators to minimize inter-observer bias; characteristics were classified as follows: persistent desquamation, persistent erythema, a mottled appearance (erythema and white patches), and a plaque (solid, raised, flat lesion >1 cm) and/ or an erosion/ulceration that could not be attributed to other dermatological disorders (modified from Ribeiro et al.) (3). Patients with uncertain eroded/ulcerated lesions underwent a biopsy to exclude SCC. A binary regression logistic analysis was performed to determine the significant associations with each clinical form of AC. Univariate and multivariate analyses of the different variables related to other markers of actinic damage (lentigines and actinic keratosis (AK)) in patients with AC were also analysed.The study protocol was approved by the Research Ethics Committee of Pontevedra-Vigo-Ourense, Spain (protocol number 2015/582).All statistical analyses were performed using SPSS 22.0 statistical software for Windows. RESULTSA total of 1,250 patients were selected for the study. Eleven patients declined to participate in the study or were not willing to sign the consent form; therefore, a total of 1,239 patients completed the screening form. Of these, 410 were diagnosed with AC, and complete data were available for 408 patients. The prevalence of AC in the study population was 31.3% (95% confidence interval (95% CI) 28.7-33.8).Regarding AC clinical manifestations, 47.3% (193) of patients had only one clinical manifestation of AC,...

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Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain

Cited by 35 publications

References 19 publications

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype

Use of lip photoprotection in patients suffering from actinic cheilitis

Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage

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