Acteoside inhibits type Ι allergy through the down-regulation of Ca/NFAT and JNK MAPK signaling pathways in basophilic cells

Motojima, Hideko; Villareal, Myra O.; Iijima, Rieko; Han, Jianzhong; Isoda, Hiroko

doi:10.1007/s11418-013-0753-4

Cited by 27 publications

(16 citation statements)

References 35 publications

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“…Since pro-inflammatory cytokines are regulated by NFAT-dependent mechanisms 20 , the anti-inflammatory effects by H 2 can be explained by the suppression of NFAT. Additionally, the anti-allergic effects of H 2 can be explained by the decrease in Ca 2+ /NFAT signaling 33 .…”

Section: Discussionmentioning

confidence: 99%

Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

Iuchi

Imoto

Kamimura

et al. 2016

Sci Rep

103

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We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 in therapeutic and preventive medicine. Moreover, H2 regulates various signal transduction pathways and the expression of many genes. However, the primary targets of H2 in the signal transduction pathways are unknown. Here, we attempted to determine how H2 regulates gene expression. In a pure chemical system, H2 gas (approximately 1%, v/v) suppressed the autoxidation of linoleic acid that proceeds by a free radical chain reaction, and pure 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC), one of the major phospholipids, was autoxidized in the presence or absence of H2. H2 modified the chemical production of the autoxidized phospholipid species in the cell-free system. Exposure of cultured cells to the H2-dependently autoxidized phospholipid species reduced Ca2+ signal transduction and mediated the expression of various genes as revealed by comprehensive microarray analysis. In the cultured cells, H2 suppressed free radical chain reaction-dependent peroxidation and recovered the increased cellular Ca2+, resulting in the regulation of Ca2+-dependent gene expression. Thus, H2 might regulate gene expression via the Ca2+ signal transduction pathway by modifying the free radical-dependent generation of oxidized phospholipid mediators.

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Section: Discussionmentioning

confidence: 99%

Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

Iuchi

Imoto

Kamimura

et al. 2016

Sci Rep

103

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“…The naturally occurring water-soluble phenylethanoid glycoside down-regulates Ca 2? -dependent MAPK signaling in basophilic cells (Motojima et al 2013). It appears to become involved in the inhibition of type I allergies.…”

Section: Introductionmentioning

confidence: 99%

In vitro cultures of Scutellaria alpina as a source of pharmacologically active metabolites

2015

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Callus, cell suspension, and shoot cultures as well as in vitro-derived plants of Scutellaria alpina grown under greenhouse (for 3 months) and field conditions (for 2 years) were established, and their flavonoid (baicalin, wogonoside, luteolin) and phenylethanoid glycoside (verbascoside) contents were determined by ultra performance liquid chromatography. The quantities of individual compounds were influenced by the type of analyzed plant material, its age, and day of culture passage. Undifferentiated callus and cell suspension cultures of S. alpina showed higher amounts of metabolites than the proliferating shoot cultures. The highest baicalin (26.25 mg g-1dry wt) and wogonoside (15.60 mg g-1 dry wt) levels were found in callus cultured for 1.5-2 years on MS agar medium supplemented with NAA (0.1 mg l-1) and TDZ (0.2 mg l-1), which were similar to these yielded by 3-month-old and 2-year-old plant roots of S. alpina. The maximum level of verbascoside (27.21 mg g-1 dry wt) was achieved in cell suspension culture maintained for 1 year in MS liquid medium with NAA (0.1 mg l-1) and TDZ (0.2 mg l-1). The amount was found to be about 3-4fold higher than in shoots and roots of S. alpina micropropagated plants grown in field condition (7.2-9.7 mg g-1 dry wt). Our results suggest that in vitro cultures of S. alpina represent effective system for the production of the bioactive compounds with different pharmacological activity during long-term subculturing. Keywords Cell cultures Á Flavonoid content Á Scutellaria alpina Á Shoot cultures Á Verbascoside Communicated by M. H. Walter.

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“…[59][60][61] Among them, echinacoside 62,63) (28) and acteoside [64][65][66][67] (29, also called verbascoside, kusaginin, and orobanchin) are representatives of the well-studied phenylethanoid glycosides and have been reported to possess a number of important bioactive properties such as antioxidative, neuroprotective, nitric oxide radical scavenging, antihepatotoxic, and antiosteoporotic activities. [2][3][4]6,[59][60][61][68][69][70][71][72][73][74][75][76][77] As phenylethanoid glycoside constituents from the stems of C. tubulosa, we have isolated the above-mentioned echinacoside 78) (28) and acteoside 78) (29) (54), and campneoside II 86,87) (55). Furthermore, a new and a known corresponding sugar ester, kankanose 22) (56) and cistanoside F 89) (57), were also obtained (Chart 3).…”

Section: Chemical Constituentsmentioning

confidence: 99%

A Review of Biologically Active Natural Products from a Desert Plant <i>Cistanche tubulosa</i>

et al. 2019

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An Orobanchaceae plant Cistanche tubulosa (SCHENK) WIGHT (Kanka-nikujuyou in Japanese), which is one of the authorized plant resources as Cistanches Herba in both Japanese and Chinese Pharmacopoeias, is a perennial parasitic plant growing on roots of sand-fixing plants. The stems of C. tubulosa have traditionally been used for treatment of impotence, sterility, lumbago, and body weakness as well as a promoting agent of blood circulation. In recent years, Cistanches Herba has also been widely used as a health food supplement in Japan, China, and Southeast Asian countries. Here we review our recent studies on chemical constituents from the stems of C. tubulosa as well as their bioactivities such as vasorelaxtant, hepatoprotective, and glucose tolerance improving effects.

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Acteoside inhibits type Ι allergy through the down-regulation of Ca/NFAT and JNK MAPK signaling pathways in basophilic cells

Cited by 27 publications

References 35 publications

Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

In vitro cultures of Scutellaria alpina as a source of pharmacologically active metabolites

A Review of Biologically Active Natural Products from a Desert Plant <i>Cistanche tubulosa</i>

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