Acropustulosis of infancy

Abstract

Acropustulosis of infancy (Al) is a syndrome consisting of pruritic pustules that are found primarily on the extremities of infants. It is uncommon, but not rare, and persists about two years. In two infants in whom Al began at birth, there was a striking response to sulfones. There was no response to other therapy. Laboratory findings are not diagnostic for Al. Similar histopathologic changes (subcorneal pustules) can be found in other eruptions of infancy.

Localised atypical erythema toxicum neonatorum in a term infant

“…Infantile acropustolosis 11 presents as recurrent crops of 1-2 mm pruritic vesiculo-pustules, rich in neutrophils and eosinophilis, on the distal extremities between the ages of 2 and 10 months, though onset in the neonatal period has been reported. Characteristic distribution, lack of pruritus as well as non-recurrent nature in our case, makes this diagnosis unlikely.…”

Pyodermitis of Genital Areas: An Atypical Manifestation of Eosinophilic Pustulosis of Childhood

“…Infantile acropustulosis [2] is characterized by recurrent episodes of pruriginous pustules affecting the extremities (hands and feet), with a spontaneously favourable course over several months or years. Topical corticosteroids or dapsone are useful in severe forms associated with frequent or severe episodes [3].…”

Infantile Eosinophilic Pustular Folliculitis

“…Infantile acropustulosis [22][23][24] is an uncommon idio pathic pustular dermatosis that appears between birth and 9 months of age. The eruption consists of recurrent selfhealing outbreaks of pruritic vesiculopustules, occasionally associated with peripheral eosinophilia, that last until 3 years of age.…”