Acrokeratosis paraneoplastica (Bazex' syndrome)

Abstract

A 63-year-old man had acrokeratosis paraneoplastica (Bazex' syndrome) characterized by violaceous erythema and scaling of the fingers, toes, nose, and aural helices. Severe nail dystrophy was present. Extensive examination of the patient for malignant neoplasms a few months after the initial appearance of the skin changes disclosed no abnormalities, but one year after onset, an epidermoid carcinoma of the lung was found.

Acrokeratosis Paraneoplastica (Bazex Syndrome) Presenting in a Patient with Metastatic Breast Carcinoma: Possible Etiologic Role of Zinc

“…Symptomatic treatment of acrokeratosis paraneoplastica may result in slight improvement, but lesions will usually not clear until the underlying neoplasia is successfully treated. 27 In the present case, improvement of cutaneous findings coincided with remission of the underlying malignancy. Reported examples of unsuccessful cutaneous treatments include topical keratolytics, corticosteroids, tar, antifungals, and antibiotics.…”

Bazex Syndrome (Acrokeratosis Paraneoplastica) Diagnosed in a Patient with Oral Persistent Ulcerations

“…The etiology of Bazex syndrome is still unknown, although, several hypotheses have been suggested such as immunologic mechanisms in which antibodies directed against the tumour cross-react with antigens in the epidermis or basement membrane; a possible tumour's capability to secrete growth factors, e.g., TGF-alpha that may affects epidermal growth and epithelial differentiation; and genetic susceptibility due to the occurrence of the same HLA types (A3 and B8) in many cases of the disease [8,[10][11][12].…”

Nouvelles des cliniques / Neues aus den Kliniken

“…mit einem metastasierenden Prostatakarzinom sind in der Literatur dokumentiert [1]. Die Akrokeratosis Bazex gilt als obligate Paraneoplasie [2][3][4][5].…”