Acrodermatitis Enteropathica Without Diarrhea

Portnoy, Benjamin

doi:10.1001/archderm.1961.01580090070008

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…More formal studies have shown zinc responsive impairments of monocyte and neutrophil chemotaxis (Weston et al, 1977), cutaneous hypersensitivity reactions and in vitro lymphoblast responses (Chandra, 1980). Diarrhoea was an important but not invariable feature of Acrodermatitis enteropathica (Wells and Winkelmann, 1961;Portnoy and Marsden, 1961); its development has become less frequent since clinical awareness has improved the early diagnosis of Acrodermatitis enteropathica. The aetiology of the watery diarrhoea is unknown; it may represent an intestinal infection or impaired mucosal function.…”

Section: Aggettmentioning

confidence: 99%

Acrodermatitis enteropathica

Aggett¹

1983

J of Inher Metab Disea

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Section: Aggettmentioning

confidence: 99%

Acrodermatitis enteropathica

Aggett¹

1983

J of Inher Metab Disea

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“…While this is easy when AE presents classic symptoms from intestine and skin, it becomes more difficult in forms presenting a mild course, and especially if the patient survives to adult age. Case 1 did not have intes tinal symptoms which is described by others [15]. It is uncertain whether skin symptoms can lack or be present in an abortive form, since the skin symptoms have always been decisive of the diagnosis.…”

Section: Commentmentioning

confidence: 67%

Untreated Acrodermatitis Enteropathica in Adults

Ølholm-Larsen¹

1978

Dermatology

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In the literature six cases of acrodermatitis enteropathica (AE) are described in which the patients survived to adult age. In a few of these cases the symptoms disappeared at the onset of puberty, while in the rest the disease had a fluctuating course with long symptom-free intervals and an uncharacteristic symptomatology. Two cases are reported. In case 1 there remained only characteristic skin changes on the feet at adult age, in case 2 both skin and intestinal symptoms disappeared at adult age. For long periods this patient was invalidated through depressions, a symptom which is characteristic of children suffering from an active AE. The same patient developed parkinsonism at a relatively young age. In both cases a very low serum zinc level essentially supported the diagnosis. It is possible that AE in adults is underdiagnosed because of an uncharacteristic symptomatology.

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“…At first diagnosed as impetigo (other possibilities being dermatitis herpetiformis and epidermolysis bullosa), her morose condition and complete baldness raised the question of AE in spite of the absence of gastrointestinal abnormalities. She responded rapidly to Diodoquin (commencing with 400 mg daily) and was in fact the first case of AE without diarrhoea to be reported (Portnoy & Marsden, 1961).…”

Section: Case Reportmentioning

confidence: 84%