Acoustic properties of shell-encapsulated, gas-filled ultrasound contrast agents

Hoff, Lars; Sontum, Per C.; Hoff, Brad W.

doi:10.1109/ultsym.1996.584337

Cited by 29 publications

(22 citation statements)

References 4 publications

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“…In this article, the idea introduced by Hoff (1996) to treat the shell of an encapsulated gas bubble as a viscoelastic solid was expanded to a Rayleigh-Plesset-like equation. The effective bulk modulus and friction param- eter, describing the elasticity and viscosity of the shell, are found by fitting the calculated transmission spectrum to the measured transmission spectrum.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the second-harmonic response of Quantison™ will be calculated. The approach described in this article is comparable with the viscoelastic approach described by Hoff (1996). However, his description is only valid for low acoustic amplitudes, i.e., in the linear range.…”

Section: Previous Related Workmentioning

confidence: 92%

“…For values of 88 MPa for the shell elasticity and 1.77 Pa ⅐ s for the shell viscosity, his conclusions agree with those of de Jong and Hoff (1993) concerning scattering and attenuation of Albunex. Hoff (1996) proposed an approach describing the shell of the encapsulated bubble by a complex Young's modulus derived from the Kelvin-Voigt model for viscoelastic solids. The stiffness of the shell reduces the compressibility of the particles, resulting in an increase of the resonance frequency.…”

Section: Previous Related Workmentioning

confidence: 99%

“…The last component, ␦ fr , is the damping due to internal friction or viscosity of the shell and is given by Hoff (1996):…”

Section: Theorymentioning

confidence: 99%

“…6.). K eff ϭ 78.4 MPa and S F ϭ 5.1 Pa ⅐ s. Hoff (1996) and is explained by the fact that the thickness of the Albunex shell is independent of the diameter and, therefore, the stiffness increases for smaller bubbles.…”

Section: Scattering and Attenuation Of Albunexmentioning

confidence: 99%

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Acoustic Modeling of Shell-Encapsulated Gas Bubbles

Frinking

Jong

1998

Ultrasound in Medicine & Biology

159

102

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Abstract-Existing theoretical models do not adequately describe the scatter and attenuation properties of the ultrasound contrast agents Quantison™ and Myomap™. An adapted version of the Rayleigh-Plesset equation, in which the shell is described by a viscoelastic solid, is proposed and validated for these agents and Albunex. The acoustic transmission and scattering are measured in the frequency band from 1-10 MHz. The measured transmission is used to estimate two parameters, the effective bulk modulus, K eff , describing the elasticity, and the friction parameter, S F , describing the viscosity of the shell. For the scattering, the difference between measurements and calculations is < 3 dB. For Quantison™, the effective bulk modulus is independent of the bubble diameter.

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Section: Discussionmentioning

confidence: 99%

Section: Previous Related Workmentioning

confidence: 92%

Section: Previous Related Workmentioning

confidence: 99%

“…The last component, ␦ fr , is the damping due to internal friction or viscosity of the shell and is given by Hoff (1996):…”

Section: Theorymentioning

confidence: 99%

Section: Scattering and Attenuation Of Albunexmentioning

confidence: 99%

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Acoustic Modeling of Shell-Encapsulated Gas Bubbles

Frinking

Jong

1998

Ultrasound in Medicine & Biology

159

102

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Amphiphilic Lipopeptide Microparticles as Contrast Agents for Medical Ultrasound Imaging

Cuthbertson¹,

Tornes²,

Solbakken³

et al. 2003

Macromolecular Bioscience

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In this study we investigated the utility of complementary amphiphilic lipopeptides as a new membrane formulation suitable for the preparation of gas‐filled microbubbles. Through primarily ion pairing and hydrophobic interactions we rationalized that the stacking of synthetic lipopeptides into the surface of microbubbles would make bubble suspensions useful as ultrasound contrast agents. By mixing charged lipopeptides in propylene glycol/glycerol solutions in the presence of a perfluorocarbon gas followed by vigorous shaking, microbubble suspensions were formed in good yield with a size distribution spanning the range 1–7 × 10−6 m. The microbubbles were studied in an in vivo model and provided imaging efficacy comparable with conventional ultrasound contrast agents.

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