Acoustic Overexposure Increases the Expression of VGLUT-2 Mediated Projections from the Lateral Vestibular Nucleus to the Dorsal Cochlear Nucleus

Barker, Matthew; Solinski, Hans Jürgen; Hashimoto, Haruka; Tagoe, Thomas Amatey; Pilati, Nadia; Hamann, Martine

doi:10.1371/journal.pone.0035955

Cited by 44 publications

(60 citation statements)

References 91 publications

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“…For auditory processing, early convergence occurs at the first synaptic levels in the mammalian brain stem: anatomical studies in guinea pigs (Burian and Gstoettner 1988;Burian et al 1989Burian et al , 1991, gerbils (Kevetter andPerachio 1986, 1989), rats (Barker et al 2012), and macaque monkeys (Newlands and Perachio 2003) have shown that the vestibular nerve and lateral vestibular nucleus project to the cochlear nucleus, the first station of the central auditory pathway. Proprioceptive/efference copy input is present already in the vestibular nuclei , as are visual motion signals (Waespe and Henn 1977), so vestibular pathways are likely to also convey proprioceptive and visual information.…”

Section: Auditory Vs Multimodal Spatial Representations: Behavioral mentioning

confidence: 99%

Dependence of auditory spatial updating on vestibular, proprioceptive, and efference copy signals

Genzel

Firzlaff

Wiegrebe

et al. 2016

Journal of Neurophysiology

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Humans localize sounds by comparing inputs across the two ears, resulting in a head-centered representation of sound-source position. When the head moves, information about head movement must be combined with the head-centered estimate to correctly update the world-centered soundsource position. Spatial updating has been extensively studied in the visual system, but less is known about how head movement signals interact with binaural information during auditory spatial updating. In the current experiments, listeners compared the world-centered azimuthal position of two sound sources presented before and after a head rotation that depended on condition. In the active condition, subjects rotated their head by ϳ35°to the left or right, following a pretrained trajectory. In the passive condition, subjects were rotated along the same trajectory in a rotating chair. In the cancellation condition, subjects rotated their head as in the active condition, but the chair was counter-rotated on the basis of head-tracking data such that the head effectively remained fixed in space while the body rotated beneath it. Subjects updated most accurately in the passive condition but erred in the active and cancellation conditions. Performance is interpreted as reflecting the accuracy of perceived head rotation across conditions, which is modeled as a linear combination of proprioceptive/efference copy signals and vestibular signals. Resulting weights suggest that auditory updating is dominated by vestibular signals but with significant contributions from proprioception/efference copy. Overall, results shed light on the interplay of sensory and motor signals that determine the accuracy of auditory spatial updating.

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Section: Auditory Vs Multimodal Spatial Representations: Behavioral mentioning

confidence: 99%

Dependence of auditory spatial updating on vestibular, proprioceptive, and efference copy signals

Genzel

Firzlaff

Wiegrebe

et al. 2016

Journal of Neurophysiology

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“…The vestibular inputs to the DCN are well documented (9,(26)(27)(28)(29). What role do they play in DCN processing?…”

Section: Resultsmentioning

confidence: 99%

Early multisensory integration of self and source motion in the auditory system

Wigderson

Nelken

Yarom

2016

Proc. Natl. Acad. Sci. U.S.A.

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Discriminating external from self-produced sensory inputs is a major challenge for brains. In the auditory system, sound localization must account for movements of the head and ears, a computation likely to involve multimodal integration. Principal neurons (PNs) of the dorsal cochlear nucleus (DCN) are known to be spatially selective and to receive multimodal sensory information. We studied the responses of PNs to body rotation with or without sound stimulation, as well as to sound source rotation with stationary body. We demonstrated that PNs are sensitive to head direction, and, in the presence of sound, they differentiate between body and sound source movement. Thus, the output of the DCN provides the brain with enough information to disambiguate the movement of a sound source from an acoustically identical relative movement produced by motion of the animal.dorsal cochlear nucleus | multisensory integration | sound localization A significant amount of sensory information reaching the brain of a moving organism results from the movement itself. Organisms have to disentangle self-generated sensations from the rest of the sensory input to use external sensory information for guiding behavior. To perform this disentanglement, brains integrate information from different sensory modalities and use efference copies of motor commands (1-3). This difficult challenge has been studied in several sensory-motor systems. In the visual system, the organism has to discriminate between movement of the visual scene and movement of the eyes (4, 5). Similarly, in the auditory system, it is necessary to discriminate between an actual motion of a sound source and the relative motion caused by movement of the head or the body (6). Moreover, it has recently been demonstrated that spatial acuity is improved during self-motion in comparison with sound-source motion (7). Here we show that neurons of the dorsal cochlear nucleus (DCN), which are known to be spatially selective (8,9), are affected by vestibular stimulation. We demonstrate that by integrating these two sensory modalities, the output of the DCN already contains enough information to reliably discriminate between self and sound-source motions.The DCN is a dome-like formation located on the dorsal surface of the lower medulla. Its anatomy and physiology have been thoroughly studied both in vivo and in vitro (9, 10). The principal neurons (PNs) of the DCN, the fusiform and giant cells, receive auditory information directly from the auditory nerve (11), as well as indirectly from other neurons in the cochlear nucleus. The DCN has cerebellar-like circuitry (9). A large number of granule cells contribute to a parallel fiber-like system that forms a molecular layer and conveys multimodal sensory information to the molecular layer interneurons as well as the PNs and cartwheel cells (9,(12)(13)(14) (Fig. 1A). Interneurons within the molecular layer, including the cartwheel cells, form inhibitory local networks that terminate on the PNs.Sound localization in mammals is based on binau...

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“…This is particularly prominent in the dorsal cochlear nucleus (DCN), which is known to integrate non-auditory sensory information and receives glutamatergic inputs from different parts of the vestibular nuclei (Barker et al, 2012). In gerbils and guinea pigs, there are also connections between the saccule and all auditory nuclei (Kevetter and Perachio, 1989;Gstoettner et al, 1991).…”

Section: Interaction Between Auditory and Vestibular Pathwaysmentioning

confidence: 99%