Acoustic Diagnosis Device for Dentistry

Hatori, Kouki; Saijo, Yoshifumi; Hagiwara, Yoshihiro; Naganuma, Yukihiro; Igari, Kazuko; Iikubo, Masahiro; Kobayashi, Kazuto; Sasaki, Keiichi

doi:10.1007/978-981-10-1560-1_16

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…Major advantages of SAM over other imaging techniques are no requirement of special staining and capture of an image of an area of around 5 mm x 5 mm in a couple of minutes. The speed of sound (SOS) through tissues [26][27][28][29][30][31][32][33][34][35] or acoustic impedance of samples [36,37] can be calculated by SAM, and two-dimensional distributions are mapped. Similarly, cells and organelles can be resolved by acoustic microscopy using higher frequencies of 100-1200 MHz [38][39][40][41][42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Designating Vulnerability of Atherosclerotic Plaques

Bilen¹

2020

Lipid Peroxidation Research

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Microcalcification is an indication of vulnerability of plaques in humans. With conventional imaging modalities, screening of micrometer-sized structures in vivo with high spatial resolution has not been achieved. The goal of this study is to evaluate the potentials of micro-computed tomography (micro-CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), time-resolved fluorescence spectroscopy (TRFS), scanning acoustic microscopy (SAM), and photoacoustic microscopy (PAM) in the determination of atherosclerotic plaques with microcalcifications and, therefore, the prospect of constructing a modality on a catheter system. The discrimination of microcalcifications within the fibrocalcific plaques and, therefore, the effectivity of these imaging techniques are discussed. The potential of quantum dots (QDs) in biological imaging is also elucidated since they attract great attention as contrast and therapeutic agents, owing unique properties including good light stability, low toxicity, strong fluorescence intensity, and changing emission wavelength with QD size, ranging from 10 to 100 Å in radius.

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Section: Introductionmentioning

confidence: 99%

Designating Vulnerability of Atherosclerotic Plaques

Bilen¹

2020

Lipid Peroxidation Research

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“…When compared with the techniques previously mentioned, SAM has the advantage of micro-meter level resolution, the capability of non-destructive monitoring, no requirement of a special sampling, the ability of quick measurement (less than 2 minutes for a 4.8 mm x 4.8 mm area) [11] and the applicability to tissues [12][13][14][15] or cell populations [16][17][18][19][20]. Besides, a SAM probe would enable its use in clinics [21].…”

Section: Introductionmentioning

confidence: 99%

Examination of Cerebral Aneurysm by Scanning Acoustic Microscopy

Bilen

2020

Preprint

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Background: Asymptomatic intracranial aneurysms rupture without any warning, therefore, use of high-resolution imaging techniques for the rupture risk assessment is essential. Methods: This study’s goal is to assess the feasibility of scanning acoustic microscopy (SAM) in the characterization of cerebral aneurysm. The aneurysm’s dome samples were obtained from 12 different patients with and without subarachnoid hemorrhage. Results: The acoustic impedance values are found statistically higher in samples from female patients than in samples from male patients. On the other hand, sample from a male patient without subarachnoid hemorrhage has higher acoustic impedance value when compared with samples from male patients with subarachnoid hemorrhage, however, this discrepancy is not observed in female patients. Conclusion: In summary, the success of SAM in monitoring the altering acoustic impedance values in male and female patients with and without subarachnoid hemorrhage indicates the potential of SAM for the diagnosis of instability of cerebral aneurysms.

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“…Scanning acoustic microscopy (SAM), which is a non-invasive and comparably less expensive technique, provides information about the morphology and the mechanical properties of the specimen simultaneously at microscopic levels, rapidly and without a need for special staining. Focused high frequency ultrasound signals are used to calculate either the speed of sound (SOS) through samples 9–18 or acoustic impedance of samples 19,20 . Two-dimensional maps of an area of around 5 × 5 mm are obtained in a couple of minutes.…”

Section: Introductionmentioning

confidence: 99%

Determination of Ultrastructural Properties of Human Carotid Atherosclerotic Plaques by Scanning Acoustic Microscopy, Micro-Computer Tomography, Scanning Electron Microscopy and Energy Dispersive X-Ray Spectroscopy

Bilen

Şener

Albeniz

et al. 2019

Sci Rep

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Microcalcification is the precursor of vulnerability of plaques in humans. Visualization of such small structures in vivo with high spatial resolution is an unsolved issue. The goal of this study is to evaluate the potential of scanning acoustic microscopy (SAM) in the determination of atherosclerotic plaques with calcifications by validating this technique with micro-computer tomography (micro-CT), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). The fibrocalcific plaques were obtained from 12 different patients and initially examined with micro-CT. The images exhibited calcifications within these plaques. For imaging with SAM, approximately 5 μm thick slices were prepared. Sound speed values within calcified regions were measured to be greater than the ones in collagen-rich regions. These fibrocalcific plaques were also examined with SEM and EDS revealing collagen and calcium deposition within these samples. The consistency of the results obtained by all of the modalities involved in our study is an indication of the potential of SAM as a clinical tool for the diagnosis of vulnerable plaques.

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Acoustic Diagnosis Device for Dentistry

Cited by 11 publications

References 35 publications

Designating Vulnerability of Atherosclerotic Plaques

Designating Vulnerability of Atherosclerotic Plaques

Examination of Cerebral Aneurysm by Scanning Acoustic Microscopy

Determination of Ultrastructural Properties of Human Carotid Atherosclerotic Plaques by Scanning Acoustic Microscopy, Micro-Computer Tomography, Scanning Electron Microscopy and Energy Dispersive X-Ray Spectroscopy

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