Acoustic Analysis of a Continuous-Flow Left Ventricular Assist Device before and after Suspected Pump Thrombosis

Castagna, F.; Pan, Stephen; Garan, A.R.; Yuzefpolskaya, M.; Takeda, Koji; Takayama, Hiroo; Ross, Kenneth A.; Torres, Magdalena; Blum, Raia; Singh, S.; Mancini, Donna; Naka, Yoshifumi; Colombo, P.C.; Bulek, Savaskan; Topkara, V.K.

doi:10.1016/j.healun.2016.01.932

Cited by 2 publications

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“…58,72,73 There have been several other reports investigating acoustic spectral analysis for the diagnosis of pump thrombosis in Heartmate II. [74][75][76][77][78] The studies differed in design and signal analysis method. Different authors concluded that acoustic spectral analysis may assist in the diagnosis of pump thrombosis, but concrete diagnostic criteria seemed elusive.…”

Section: Acoustic Spectral Analysismentioning

confidence: 99%

“…Unfortunately, monitoring of LVAD patients remain lacking. This is reflected by continuous efforts to improve LVAD diagnostic using new modalities as acoustic spectral analysis 58,[65][66][67][68][69][70][71][72][73][74][75][76][77][78]118 , alteration in circadian rhythm [115][116][117] , and machine learning based analysis 73 . Though this work describes signal changes in Heartware HVAD, it is reasonable to assume that the observations made are relevant with some modifications to other hydrodynamic pump types.…”

Section: Relevance Of This Thesismentioning

confidence: 99%

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Accelerometer Detects Pump Thrombosis and Thromboembolic Events in an In vitro HVAD Circuit

et al. 2018

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Pump thrombosis and stroke are serious complications of left ventricular assist device (LVAD) support. The aim of this study was to test the ability of an accelerometer to detect pump thrombosis and thromboembolic events (TEs) using real-time analysis of pump vibrations. An accelerometer sensor was attached to a HeartWare HVAD and tested in three in vitro experiments using different pumps for each experiment. Each experiment included thrombi injections sized 0.2-1.0 mL and control interventions: pump speed change, afterload increase, preload decrease, and saline bolus injections. A spectrogram was calculated from the accelerometer signal, and the third harmonic amplitude was used to test the sensitivity and specificity of the method. The third harmonic amplitude was compared with the pump energy consumption. The acceleration signals were of high quality. A significant change was identified in the accelerometer third harmonic during the thromboembolic interventions. The third harmonic detected thromboembolic events with higher sensitivity/specificity than LVAD energy consumption: 92%/94% vs. 72%/58%, respectively. A total of 60% of thromboembolic events led to a prolonged third harmonic amplitude change, which is indicative of thrombus mass residue on the impeller. We concluded that there is strong evidence to support the feasibility of real-time continuous LVAD monitoring for thromboembolic events and pump thrombosis using an accelerometer. Further in vivo studies are needed to confirm these promising findings.

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