Ações contra a Covid-19 na População com Síndrome de Down

Russo, Giorgia Castilho; Bernardes, Nathália; Baraldi, Natália Rezende; Saraiva, Denise Jeanine Berlinger; Angelis, Kátia De; Lantieri, Carla Janice Baister; Saraiva, José Francisco Kerr

doi:10.36660/abc.20200685

Cited by 3 publications

(7 citation statements)

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“…Embora as informações sobre a epidemiologia geral e as características clínicas dos pacientes com SD e infecção pelo Coronavírus ainda sejam escassas, essa população deve ser considerada de alto risco. Três associações brasileiras [Fundação Síndrome de Down (FSD), Pontifícia Universidade Católica de Campinas (PUC-Campinas) e Sociedade Brasileira de Cardiologia (SBC)] produziram, diante das medidas de contenção/isolamento social, materiais de apoio para jovens com SD e suas famílias, com o objetivo de ajudar a combater ou diminuir o contágiosabido que indivíduos com SD compartilham uma tendência a imitar e repetir comportamentos e esse padrão de função cognitiva associado ao fenótipo comportamental poderia promover a adesão das práticas preventivas ao SARS- CoV-2 (Del Carmen Ortega, 2020;Russo et al, 2020). Assim, também foi orientado aos jovens com SD que produzissem vídeos que elucidassem as práticas de prevenção contra o Coronavírus, de forma que se preservasse a interação, comunicação e socialização entre elesfatores importantes para o desenvolvimento deles e que foram afetados com o avanço da pandemia.…”

Section: Resultsunclassified

“…Ademais, ocorre variação do fenótipo imunológico com a idade, em razão de alterações na regulação de citocinas; assim, as crianças são mais suscetíveis, enquanto os adultos frequentemente apresentam aumento dos biomarcadores pró-inflamatórios. Essas alterações podem ter impacto nas doenças anatômicas dos pacientes e aumentar a prevalência de condições inflamatórias crônicas, cardiopatias, doenças autoimunes e mortalidade por sepse (Faundes et al, 2021;Russo et al, 2020;Vita et al, 2020), de modo que as alterações anatômicas propiciam a colonização e, com isso, a infecção de vias aéreas superiores, bem como as cardiopatias influenciam no desfecho grave da COVID-19, acarretando uma maior mortalidade. No entanto, especula-se que infecções virais repetidas nos primeiros anos de vida podem aumentar a imunidade humoral e celular natural, o que explicaria a diminuição das infecções com a idade (Correia et al, 2020;Krishnan et al, 2020;Kim-Hellmuth et al, 2021).…”

Section: Introductionunclassified

“…Atualmente, para prevenir a infecção pelo Coronavírus é necessário que evite-se a exposição ao vírus: os achados científicos sugerem fortemente que o isolamento de casos, combinados à quarentena e ao distanciamento social, têm o potencial de diminuir a transmissão da doença. Todavia, indivíduos com SD necessitam de socialização para uma melhor qualidade de vida e autonomia, de maneira que o isolamento social pode representar um grande desafio para essa população (Aquino;Lima, 2020;Russo et al, 2020).…”

Section: Introductionunclassified

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A Síndrome de Down ante a infecção por Coronavírus

Silva¹,

Nunes²,

França³

et al. 2021

RSD

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Este estudo teve como objetivo elucidar de que forma as alterações genéticas provocadas pela Síndrome de Down (SD) impactam nos casos de acometimento pelo SARS-CoV-2, além de expor como o isolamento social pode afetar negativamente a vida de indivíduos com SD. O estudo adotou o modelo de revisão literária qualitativa, através das bases de dados Google Acadêmico, SciELO e PubMed, por meio dos descritores “Down Syndrome” e “Coronavirus”, sendo selecionados vinte artigos. Percebeu-se que a SD é a forma genética mais comum de deficiência intelectual e as alterações que a trissomia do cromossomo 21 acarretam, impactam significativamente no curso da doença de pessoas com SD infectadas pelo Coronavírus, já que o sistema imune delas é hiperativado, com capacidade para gerar uma chuva de citocinas, que facilitará a entrada do vírus nas células, favorecendo, assim, a replicação viral. Ademais, notou-se que, mesmo o isolamento social sendo eficaz no combate à pandemia, ele pode acarretar diversos danos à saúde da população com SD, o que pode agravar certas comorbidades pré-existentes nesse grupo. Portanto, é muito relevante a vigilância e a capacitação dessa população e de suas famílias, para que previnam-se de forma correta – com técnica eficaz de lavagem de mãos e uso de equipamentos de barreira – minimizando a exposição ao vírus; e a socialização e a prática de atividade física – mesmo durante os períodos de quarentena e de forma remota – de maneira que preserve-se a saúde emocional e física desses indivíduos.

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Section: Resultsunclassified

Section: Introductionunclassified

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A Síndrome de Down ante a infecção por Coronavírus

Silva¹,

Nunes²,

França³

et al. 2021

RSD

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“…Since the COVID-19 pandemic started, behavioral actions have been a vital tool to prevent infection by SARS-CoV-2. In this context, Russo et al 74 described positive results by using educational activities developed by organizations that support individuals with DS and conducted by multi-professional teams during the pandemic. Support strategies centered on the individual with DS and their caregivers, as well as healthy eating and physical activity habits, were shown to be fundamental approaches for COVID-19 prevention in the DS population.…”

Section: Discussionmentioning

confidence: 99%

Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review

Silva,

Pereira,

Avó

et al. 2024

Sao Paulo Med. J.

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BACKGROUND: Down syndrome (DS) is a non-rare genetic condition that affects approximately 1 in every 800 live births worldwide. Further, it is associated with comorbidities, anatomical alterations of the respiratory tract, and immunological dysfunctions that make individuals more susceptible to respiratory infections. OBJECTIVE: To systematize the current scientific knowledge about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among individuals with DS. DESIGN AND SETTING: This integrative review was conducted at the Universidade Federal de São Carlos, São Paulo, Brazil. METHODS: This review was conducted in the following databases: the Virtual Health Library (Biblioteca Virtual em Saúde, BVS), PubMed, and Web of Science, using MeSH descriptors. The search included English or Portuguese studies published between January 1, 2020, and October 14, 2022. RESULTS: A total of 55 articles from 24 countries were selected, comprising 21 case-control or cohort studies, 23 case reports or series, and 11 narrative reviews or opinion studies. The articles were grouped into five categories: previous comorbidities, coronavirus disease 2019 (COVID-19) clinical features and evolution, cytokine storm and interleukins, living in institutions as a risk factor, and behavioral actions as a protective factor against SARS-CoV-2 infection. CONCLUSION: Individuals with DS are more susceptible to COVID-19 infection due to variables such as previous comorbidities, immunological factors, and their habitable environments. These aspects confer a higher risk of infection and an unfavorable clinical course. The precise pathways involved in the pathophysiology of COVID-19 in individuals with DS are not clear, thus requiring further studies. SYSTEMATIC REVIEW REGISTRATION: The Open Science Framework registered the research protocol (https://osf.io/jyb97/).

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“…Public health measures aiming to prevent the disease, such as early containment and valuable advice for patients with DS, are relevant and necessary (Dard et al 2020 ). In Brazil, to the best of our knowledge, three institutions (Down Syndrome Foundation, Pontifical Catholic University of Campinas, and Brazilian Cardiology Society) developed support materials to instruct patients with DS and their families in primary health care prevention, which was quite helpful (Russo et al 2020 ). Families of patients with DS and individuals in contact with them must follow prevention measures (Cammarata-Scalisi et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and comorbidities of COVID-19 in unvaccinated patients with Down syndrome: first year report in Brazil

et al. 2022

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Patients with Down syndrome (DS) are more affected by the Coronavirus Disease (COVID)-19 pandemic when compared with other populations. Therefore, the primary aim of our study was to report the death (case fatality rate) from SARS-CoV-2 infection in Brazilian hospitalized patients with DS from 03 January 2020 to 04 April 2021. The secondary objectives were (i) to compare the features of patients with DS and positive for COVID-19 (G1) to those with DS and with a severe acute respiratory infection (SARI) from other etiological factors (G2) to tease apart the unique influence of COVID-19, and (ii) to compare the features of patients with DS and positive for COVID-19 to those without DS, but positive for COVID-19 (G3) to tease apart the unique influence of DS. We obtained the markers for demographic profile, clinical symptoms, comorbidities, and the clinical features for SARI evolution during hospitalization in the first year of the COVID-19 pandemic in Brazil from a Brazilian open-access database. The data were compared between (i) G1 [1619 (0.4%) patients] and G2 [1431 (0.4%) patients]; and between (ii) G1 and G3 [222,181 (64.8%) patients]. The case fatality rate was higher in patients with DS and COVID-19 (G1: 39.2%), followed by individuals from G2 (18.1%) and G3 (14.0%). Patients from G1, when compared to G2, were older (≥ 25 years of age), presented more clinical symptoms related to severe illness and comorbidities, needed intensive care unit (ICU) treatment and non-invasive mechanical ventilation (MV) more frequently, and presented a nearly two fold-increased chance of death (OR = 2.92 [95% CI 2.44–3.50]). Patients from G1, when compared to G3, were younger (< 24 years of age), more prone to nosocomial infection, presented an increased chance for clinical symptoms related to a more severe illness; frequently needed ICU treatment, and invasive and non-invasive MV, and raised almost a three fold-increased chance of death (OR = 3.96 [95% CI 3.60–4.41]). The high case fatality rate in G1 was associated with older age (≥ 25 years of age), presence of clinical symptoms, and comorbidities, such as obesity, related to a more severe clinical condition. Unvaccinated patients with DS affected by COVID-19 had a high case fatality rate, and these patients had a different profile for comorbidities, clinical symptoms, and treatment (such as the need for ICU and MV) when compared with other study populations. Supplementary Information The online version contains supplementary material available at 10.1007/s00439-022-02468-3.

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Ações contra a Covid-19 na População com Síndrome de Down

Cited by 3 publications

References 5 publications

A Síndrome de Down ante a infecção por Coronavírus

A Síndrome de Down ante a infecção por Coronavírus

Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review

Clinical characteristics and comorbidities of COVID-19 in unvaccinated patients with Down syndrome: first year report in Brazil

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