Acneform Eruptions Induced by Drugs and Chemicals

Hitch, J. M.

doi:10.1001/jama.1967.03120230131020

Cited by 28 publications

(9 citation statements)

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“…However, several characteristics that are summarized in table II may be of help to support a potential relationship between drug ingestion and acne. [1,2] Taken one by one, these criteria are not enough to make the diagnosis as, for instance, some drugs may be responsible for retentional acneiform lesions. However, taken all together, these criteria may shed light on the imputability of a treatment.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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Drug-induced acne is a specific subset of acne that usually has some specific features, namely a monomorphic pattern, an unusual location of the lesions beyond the seborrheic areas, an unusual age of onset, a resistance to conventional acne therapy and, of course, the notion of a recent drug introduction. Many drugs can be responsible for such a clinical pattern. Corticosteroids, neuropsychotherapeutic drugs, antituberculosis drugs, and immunomodulating molecules are the more classical drugs associated with induced acne. Recently, new drugs, mainly targeted therapy in the field of oncology, such as epidermal growth factor receptor inhibitors, have been associated with an increased frequency of this adverse effect. Disruption of the culprit drug is rarely mandatory in cases of drug-induced acne. Close cooperation between the dermatologist and medical staff in charge of the patient is an important challenge to achieve optimal management of the initial disease.

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Section: Diagnostic Criteriamentioning

confidence: 99%

Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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“…Drug-induced acneiform or follicular eruptions are usually caused either by hormones (testosterone, glucocorticoids, ACTH, oestrogen, progesterone) or halogens (iodine, bromine). Other medications which have been incriminated include quinine, disulfram, cod liver oil, thiouracil, thiourea, chloral and trimethadione (Hitch, 1967). Weary et al (1969) were the first to recognize that the tetracyclines are capable of producing acneiform eruptions.…”

Section: Discussionmentioning

confidence: 99%

Acneiform Eruption From Tetracycline

Bean

1971

Br J Dermatol

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“…Proposed diagnostic criteria include an acute pustular eruption, fever above 38 o C, neutrophilia with or without a mild eosinophilia , subcorneal or intraepidermal pustules on skin biopsy;spontaneous resolution in less than 15 days [64]. Some other ADRs are acneiform eruptions [65], fixed drug eruption [66] drug induced pemphigus and bullous pemphigoid [67] and "lupus eraythematosus-like syndrome" [68]. The pseudolymphoma syndrome is associated with a number of anticonvulsant drugs and is characterised by fever, generalized rash, lymphadenopathy, hepatosplenomegaly, abnormal liver function tests, arthralgia, eosinophilia and dyscrasias [10].…”

Section: Acute Generalized Exanthematous Pustulosismentioning

confidence: 99%

Mechanisms of Drug Hypersensitivity Reactions and the Skin

Kuljanac

2008

IAD

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The skin is an organ most often affected by adverse drug reactions. Because of limited reactivity of the skin, different drugs may induce the same reactions on the skin, even if the same drug may induce different adverse drug reactions. Many of these adverse drug reactions do not include immunological mechanisms, most of them are non-immunological processes. Adverse drug reactions which involve an immune system, may appear different times after drug administration. The severity of reactions is not dependent on the time at which adverse drug reaction appeared, even if some life threatening adverse drug reactions appear immediately after a drug administration. Four types of immunological reactions, (according to Cooms and Gell), may be involved in a drug adverse reaction. The first type of reaction (anaphylactic reaction) begins early after drug administration and different severities of the reactions could exist. The second type, known as cytotoxic hypersensitivity, begins after some minutes to a few hours after a drug administration. Third and fourth types of immunological reactions begin usually hours to days after drug administration. Some types of immunological reactions may begin days to weeks after drug administration. Sensitization to the drugs must be happen early, since re-exposition to the drug leads to the adverse drug reactions. The way of sensitization sometimes determines which immune mechanism will be involved and which clinical reaction will appear. Tests in vivo and in vitro can be used in the diagnosis of adverse drug reactions. All these tests are more or less limited to a false positive or false negative reaction and possibilities of serious reactions in tests. Provocations tests give the most satisfactory results but they may be dangerous and life threatening. We must carefully choose the skin tests and apply them according to the suspected pathomechanism of adverse drug reaction geneses and estimate the usefulness and the risks of the tests. Serious adverse drug reactions (i.e. Sy Steven-Johnson, lupus-like disease etc.) should not be tested. Some novel patents will have important implications in administration, diagnosis, and prevention of adverse drug reactions.

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Acneform Eruptions Induced by Drugs and Chemicals

Cited by 28 publications

References 0 publications

Drug-Induced Acneiform Eruption

Drug-Induced Acneiform Eruption

Acneiform Eruption From Tetracycline

Mechanisms of Drug Hypersensitivity Reactions and the Skin

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