Acneform Dermatosis Produced by Ortho (2 Chlorophenyl) Phenol Sodium and Tetra-Chlorphenol Sodium

Butler, Milton G.

doi:10.1001/archderm.1937.01470200051006

Cited by 7 publications

(1 citation statement)

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“…Chlorinated phenols were first produced commercially in the United States in the middle 1930s; chloracne, a severe refractory follicular hyperkeratosis caused by exposure to certain halogenated aromatic hydrocarbons [Crow, 1970;Crow, 1978;Taylor, 19741, was found in workers manufacturing or using the finished products as early as 1936 [Butler, 1937;Anonymous, 1936;Stingily, 19401. Widespread production of 2,4,5-T and its precursor trichlorophenol began in the late 1940s.…”

Section: Effects In Humansmentioning

confidence: 99%

Health status of workers with past exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in the manufacture of 2,4,5‐trichlorophenoxyacetic acid: Comparison of findings with and without chloracne

Moses

Lilis

Crow

et al. 1984

American J Industrial Med

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Chloracne was found in 52% of 226 workers in a 1979 cross-sectional survey at a plant where 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) had been manufactured from 1948 to 1969. Mean duration of residual chloracne was 26 years, and in 29 subjects, it had been present for 30 years. A significant increased prevalence of abnormal gamma-glutamyl transpeptidase (GGT) and higher mean GGT were found in those with chloracne, compared to those without. Although mean triglyceride values were higher in those with chloracne, the difference was not statistically significant. Neurological examination showed a statistically significant higher prevalence of abnormal sensory findings in those with chloracne. Increased prevalence of angina and reported myocardial infarction in those with chloracne was not significant when age-adjusted. Increased prevalence of reported sexual dysfunction and decreased libido in those with chloracne compared to those without was statistically significant after age adjustment. No differences were found between those with and without chloracne in serum cholesterol, total urinary porphyrins, or in reproductive outcome.

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Section: Effects In Humansmentioning

confidence: 99%