Acne Vulgaris Treated With. Vitamin A

Lynch, Francis W.

doi:10.1001/archderm.1947.01520030048006

Cited by 34 publications

(11 citation statements)

References 4 publications

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“…Most trials suffered from lack of proper control cases. The place of vitamin A in therapy therefore did not appear to us to be established on firm grounds, especially as further workers -Lynch and Cook (1947) and Mitchell and Butterworth (1951)-found their results disappointing. It seemed that with a long-term and fluctuating condition such as acne there was a good case for a double-blind therapeutic trial, using an objective method of assessment to judge results.…”

Section: Vitamin a In Acne Vulgarismentioning

confidence: 90%

Vitamin A in Acne Vulgaris

1963

BMJ

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Section: Vitamin a In Acne Vulgarismentioning

confidence: 90%

Vitamin A in Acne Vulgaris

1963

BMJ

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“…(1) 37 patients received 5% sulfur and 3% resorcinol in a bland shake lotion; (2) 49 received 5% benzoyl peroxide (Vanoxide) ; (3) 103 were treated with 0.1% vitamin A acid in a clear vehicle consisting of equal parts of 95% ethyl alcohol and propylene glycol; (4) 40 con-trol subjects received the alcohol-propylene glycol vehicle. The subjects used their preparation once or twice daily, according to individual tolerance.…”

Section: Methodsmentioning

confidence: 99%

Topical Vitamin A Acid in Acne Vulgaris

Kligman¹,

Fulton²,

Plewig³

1969

Arch Dermatol

250

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“…The first clinical observations of the effects of vitamin A and acne were reported in the forties (11)(12)(13). The study by J. Straumfjord was particularly encouraging, because improvement was seen in 74-84% of patients who were treated with vitamin A at a dose of 100,000 IV daily for at least 6 months.…”

Section: Vitamin a (Retinol)mentioning

confidence: 98%

Historical Aspects of the Oral Use of Retinoids in Acne

Hartmann

Bollag

1993

The Journal of Dermatology

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A number of investigations of the effects of vitamin A deficiency in animals and man and its treatment with natural products containing vitamin A were carried out in the twenties and thirties. In 1942, a clinical study in patients with acne treated with vitamin A yielded encouraging results. Further trials in the forties and fifties, trying to confirm the beneficial effect of oral vitamin A in acne, met with equivocal success. In the sixties, all-trans retinoic acid (tretinoin) became clinically available, and its topical efficacy in acne could be demonstrated. In 1971, oral tretinoin also was shown to be active in patients with acne. Coincidentally, the efficacy of oral 13-cis retinoic acid (isotretinoin) became evident in a series of unpublished studies in Europe. Then, in 1978, a trial carried out at the NIH, Bethesda, Maryland, yielded convincing evidence that isotretinoin is a potent new drug for the treatment of severe cystic acne. In 1982, isotretinoin was registered in the United States and one year later in Europe for the treatment of severe, recalcitrant, cystic acne. Since then, many thousands of patients suffering psychologically and physically from the severity of their disease have been treated successfully with this drug. However, the main concern of physicians prescribing isotretinoin has to focus on its potentially severe side effects, particularly its teratogenicity.

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Acne Vulgaris Treated With. Vitamin A

Cited by 34 publications

References 4 publications

Vitamin A in Acne Vulgaris

Vitamin A in Acne Vulgaris

Topical Vitamin A Acid in Acne Vulgaris

Historical Aspects of the Oral Use of Retinoids in Acne

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