Acne vulgaris and free fatty acids. A review and criticism

Voss, J. G.

doi:10.1001/archderm.109.6.894

Cited by 13 publications

(14 citation statements)

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“…on May 9, 2018 by guest http://aac.asm.org/ Downloaded from 16 P. acnes strains and found that benzylpenicillin, cephalothin, tetracycline, chloramphenicol, erythromycin, rifampin, and lincomycin were highly active but that the aminoglycoside antibiotics were only poorly active. Our data confirm and extend these observations.…”

Section: Discussionmentioning

confidence: 99%

“…Propionibacterium acnes can regularly be isolated from acne vulgaris lesions (14) and frequently from actinomycotic (9) or nonspecific anaerobic infectious processes (13). There seems to be strong evidence that P. acnes is an important etiological factor in acne vulgaris because of the release of large amounts of free fatty acids from sebum triglycerides (16). Furthermore, in acne vulgaris only those antimicrobial agents that are able to attack P. acnes appear to be therapeutic (6).…”

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confidence: 99%

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Antimicrobial Susceptibility of Propionibacterium acnes and Related Microbial Species

Hoeffler

Pulverer

1976

Antimicrob Agents Chemother

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The minimal inhibitory concentrations of 32 antimicrobial agents were established for 73 strains of Propionibacterium acnes and four related species (P. granulosum, P. avidum, Corynebacterium minutissimum, and C. parvum). Most strains showed good susceptibility to those agents usually considered active against gram-positive organisms. With the exception of C. minutissimum, the strains tested revealed more or less identical susceptibility ranges. The lowest minimal inhibitory concentrations were observed with benzylpenicillin, ampicillin, cephalothin, rifampin, erythromycin, clindamycin, and minocycline. C. minutissimum was more susceptible to gentamicin, sisomicin, tobramycin, and fusidic acid but more resistant to most other drugs than were the other species examined.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Antimicrobial Susceptibility of Propionibacterium acnes and Related Microbial Species

Hoeffler

Pulverer

1976

Antimicrob Agents Chemother

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“…The most common profile of irritant FAs consists of saturated FAs between C8 and C12 [38–40]. In our study population, we did not observe FAs smaller than C12.…”

Section: Discussionmentioning

confidence: 42%

Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation

Costa

Talarico

Duarte

et al. 2013

Dermatology Research and Practice

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Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods. Forty-five male volunteers with inflammatory acne vulgaris were treated with 300 mg of lymecycline per day, with 540 mg of γ-linolenic acid, 1,200 mg of linoleic acid, and 510 mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids' chromatographic analysis. Results. Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris.

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“…Quando os AG estão livres no SB (ou seja, os AGL), eles têm potencial citotóxico in vitro, para 100% dos leucócitos mononucleares; a remoção destes lípides, elimina esta situação e, consequentemente, contribui para a atenuação da inflamação peri-glandular dérmica (Tucker et al, 1980). Percebe-se, porém, que a capacidade irritante dos AGL é mais vista em pacientes com AV, e menos nos pacientes sem acne (Voss, 1974).…”

Section: Ou III Em Uso Sistêmico De Limeciclina E/ou Suplementaçãunclassified

“…Obviamente, nesses testes epicutâneos, usaram-se concentrações de AGL infinitamente maiores que as fisiologicamente encontradas no SB, demonstrando que tal resposta era dose-dependente (Kellum, 1968;Stillman et al, 1975), o que já foi, também, relatado por Voss (1974). Essa condição favorece uma situação pró-comedogênica: acreditamos que, fisiologicamente, esse efeito irritativo poderia ocorrer com microdoses destes AGL encontradas no SB de pacientes com AV, mesmo sendo inferiores às doses experimentais descritas neste estudo.…”

Section: Análise Dos Achados Da Cromatografia Gasosaunclassified

Estudo das mudanças quali e quantitativas da participação de ácidos graxos no sebo de pacientes com acne inflamatória, graus II ou III, em uso sistêmico de limeciclina e/ou suplementação oral à base de ácidos linoleico, gamalinolênico

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Acne vulgaris and free fatty acids. A review and criticism

Cited by 13 publications

References 0 publications

Antimicrobial Susceptibility of Propionibacterium acnes and Related Microbial Species

Antimicrobial Susceptibility of Propionibacterium acnes and Related Microbial Species

Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation

Estudo das mudanças quali e quantitativas da participação de ácidos graxos no sebo de pacientes com acne inflamatória, graus II ou III, em uso sistêmico de limeciclina e/ou suplementação oral à base de ácidos linoleico, gamalinolênico

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