Acne Urticata Polycythemica

Cutaneous mononuclear cells and eosinophils are significantly increased after warm water challenge in pruritic areas of polycythemia vera

“…In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge. The latter is reminiscent of early dermatitis and confirms the previous reports 2,5 . However, the marked changes in mast cells morphology in PV, apart from post‐warm water contact degranulation, are probably related to their neoplastic nature.…”

“…Increased cutaneous infiltrating cells in the dermis and even the epidermis in warm water-induced pruritus in PV have frequently been reported and it has been suggested that they may have a role in mediating itching. 2,5 The present study showed almost normal histological features in healthy controls with few cells, the most abundant in the papillary dermis and perivascularly and the least at the dermalepidermal junction irrespective of water temperature. 9 In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge.…”

“…The latter is reminiscent of early dermatitis and confirms the previous reports. 2,5 However, the marked changes in mast cells morphology in PV, apart from post-warm water contact degranulation, are probably related to their neoplastic nature. The presence of exocytosis at the sites of stinging sensation indicates that pruritus in PV is associated with microscopic changes without visible clinical skin lesions and so justifies its inclusion among the growing list of invisible dermatoses.…”

“…It has been suggested that the increase in cutaneous cellular infiltrates following warm water exposure may play a significant role in inducing itching. 2,4,5 The present study was conducted to qualitatively and quantitatively assess the type, cutaneous distribution and magnitude of the infiltrating mononuclear cells, eosinophils and mast cells after warm water provocation in PV.…”

Cutaneous mononuclear cells and eosinophils are significantly increased after warm water challenge in pruritic areas of polycythemia vera

“…In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge. The latter is reminiscent of early dermatitis and confirms the previous reports 2,5 . However, the marked changes in mast cells morphology in PV, apart from post‐warm water contact degranulation, are probably related to their neoplastic nature.…”

“…Increased cutaneous infiltrating cells in the dermis and even the epidermis in warm water-induced pruritus in PV have frequently been reported and it has been suggested that they may have a role in mediating itching. 2,5 The present study showed almost normal histological features in healthy controls with few cells, the most abundant in the papillary dermis and perivascularly and the least at the dermalepidermal junction irrespective of water temperature. 9 In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge.…”

“…The latter is reminiscent of early dermatitis and confirms the previous reports. 2,5 However, the marked changes in mast cells morphology in PV, apart from post-warm water contact degranulation, are probably related to their neoplastic nature. The presence of exocytosis at the sites of stinging sensation indicates that pruritus in PV is associated with microscopic changes without visible clinical skin lesions and so justifies its inclusion among the growing list of invisible dermatoses.…”

“…It has been suggested that the increase in cutaneous cellular infiltrates following warm water exposure may play a significant role in inducing itching. 2,4,5 The present study was conducted to qualitatively and quantitatively assess the type, cutaneous distribution and magnitude of the infiltrating mononuclear cells, eosinophils and mast cells after warm water provocation in PV.…”

Polycythaemia rubra vera with lamellar dystrophy of the nails: a report of two cases

“…Among the most common are bruising, purpura, a dry eczematous skin and pruritus exacerbated by bathing (Wintrobe, 1974). Other conditions include acne urticata (Baxter & Lockwood, 1958), urticaria pigmentosa (Diamond & Gross, 1966) and eosinophilic spongiosis (Black, 1977). Vascular complications are also common (Brown & Giffin, 1930;Barabas, Offen & Meinhard, 1973).…”

Cutaneous mononuclear cells and eosinophils are significantly increased after warm water challenge in pruritic areas of polycythemia vera

“…In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge. The latter is reminiscent of early dermatitis and confirms the previous reports 2,5 . However, the marked changes in mast cells morphology in PV, apart from post‐warm water contact degranulation, are probably related to their neoplastic nature.…”

“…Increased cutaneous infiltrating cells in the dermis and even the epidermis in warm water-induced pruritus in PV have frequently been reported and it has been suggested that they may have a role in mediating itching. 2,5 The present study showed almost normal histological features in healthy controls with few cells, the most abundant in the papillary dermis and perivascularly and the least at the dermalepidermal junction irrespective of water temperature. 9 In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge.…”

“…The latter is reminiscent of early dermatitis and confirms the previous reports. 2,5 However, the marked changes in mast cells morphology in PV, apart from post-warm water contact degranulation, are probably related to their neoplastic nature. The presence of exocytosis at the sites of stinging sensation indicates that pruritus in PV is associated with microscopic changes without visible clinical skin lesions and so justifies its inclusion among the growing list of invisible dermatoses.…”

“…It has been suggested that the increase in cutaneous cellular infiltrates following warm water exposure may play a significant role in inducing itching. 2,4,5 The present study was conducted to qualitatively and quantitatively assess the type, cutaneous distribution and magnitude of the infiltrating mononuclear cells, eosinophils and mast cells after warm water provocation in PV.…”

Polycythaemia rubra vera with lamellar dystrophy of the nails: a report of two cases

“…Among the most common are bruising, purpura, a dry eczematous skin and pruritus exacerbated by bathing (Wintrobe, 1974). Other conditions include acne urticata (Baxter & Lockwood, 1958), urticaria pigmentosa (Diamond & Gross, 1966) and eosinophilic spongiosis (Black, 1977). Vascular complications are also common (Brown & Giffin, 1930;Barabas, Offen & Meinhard, 1973).…”

Cutaneous mononuclear cells and eosinophils are significantly increased after warm water challenge in pruritic areas of polycythemia vera

“…In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge. The latter is reminiscent of early dermatitis and confirms the previous reports 2,5 . However, the marked changes in mast cells morphology in PV, apart from post‐warm water contact degranulation, are probably related to their neoplastic nature.…”

“…Increased cutaneous infiltrating cells in the dermis and even the epidermis in warm water-induced pruritus in PV have frequently been reported and it has been suggested that they may have a role in mediating itching. 2,5 The present study showed almost normal histological features in healthy controls with few cells, the most abundant in the papillary dermis and perivascularly and the least at the dermalepidermal junction irrespective of water temperature. 9 In contrast, evident exocytosis by mononuclear cells, and to a lesser extent eosinophils amid focal spongiosis, was seen only in cases of PV following warm water challenge.…”

“…The latter is reminiscent of early dermatitis and confirms the previous reports. 2,5 However, the marked changes in mast cells morphology in PV, apart from post-warm water contact degranulation, are probably related to their neoplastic nature. The presence of exocytosis at the sites of stinging sensation indicates that pruritus in PV is associated with microscopic changes without visible clinical skin lesions and so justifies its inclusion among the growing list of invisible dermatoses.…”

“…It has been suggested that the increase in cutaneous cellular infiltrates following warm water exposure may play a significant role in inducing itching. 2,4,5 The present study was conducted to qualitatively and quantitatively assess the type, cutaneous distribution and magnitude of the infiltrating mononuclear cells, eosinophils and mast cells after warm water provocation in PV.…”

Polycythaemia rubra vera with lamellar dystrophy of the nails: a report of two cases

“…Among the most common are bruising, purpura, a dry eczematous skin and pruritus exacerbated by bathing (Wintrobe, 1974). Other conditions include acne urticata (Baxter & Lockwood, 1958), urticaria pigmentosa (Diamond & Gross, 1966) and eosinophilic spongiosis (Black, 1977). Vascular complications are also common (Brown & Giffin, 1930;Barabas, Offen & Meinhard, 1973).…”