Acinic Cell Carcinoma of Minor Salivary Glands: A Clinicopathologic Study of 21 Cases

Omlie, Jessica E.; Koutlas, Ioannis G.

doi:10.1016/j.joms.2010.04.003

Cited by 39 publications

(37 citation statements)

References 12 publications

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“…In our experience with extraparotid MASCs diagnosed as ACC, the clinical significance of the misclassification was minimal: only 1 of 11 MASCs recurred and none metastasized [2]. This low-grade behavior was similar to the indolent behavior reported for intra-oral ACCs [22][23][24][25].…”

Section: Treatment and Prognosissupporting

confidence: 59%

Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands

Bishop

2013

Head and Neck Pathol

117

142

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Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is characterized by its striking morphologic and molecular similarities to secretory carcinoma of the breast. This review highlights the characteristic clinical, histologic, immunophenotypic, and molecular features of MASC, and draws attention to the differential diagnosis of this increasingly recognized tumor.

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Section: Treatment and Prognosissupporting

confidence: 59%

Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands

Bishop

2013

Head and Neck Pathol

117

142

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“…The buccal mucosa is the most frequent site for ACC of the minor salivary gland (33%) and up to 9.5% of cases are found in the retromolar trigone [20]. Most patients are asymptomatic and the tumor is usually found during a routine dental exam, as it was with our case.…”

Section: Discussionsupporting

confidence: 60%

Acinic cell carcinoma of the retromolar trigone region: expanding the tumor phenotype in Cowden syndrome?

et al. 2011

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Cowden syndrome (CS) is a cancer predisposition syndrome caused by germline mutations in the PTEN tumor suppressor gene. It is associated with an increased risk of thyroid, breast and endometrial cancer but many manifestations can be found in the head and neck region, some of which are pathognomonic. Here we report a 35-year-old male referred by his dentist for evaluation of a lesion located near the retromolar trigone. Comprehensive clinical examination revealed papillomatous skin lesions, macrocephaly and gingival hypertrophy. Histopathological examination of the lesion showed an acinic cell carcinoma (ACC) of minor salivary gland origin. Analysis of the PTEN gene identified a germline R130Q mutation in exon 5, confirming the diagnosis of CS, but no loss of heterozygosity was seen in DNA extracted from tumor tissue. This is to our knowledge the first case describing an association of ACC of the minor salivary gland with a PTEN-gene related disorder. It emphasizes the importance of head and neck examination in these patients.

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“…It is a relatively slowly growing tumor but has a propensity for late recurrence or metastasis, often years after initial presentation. 1,2,4,5 Approximately 20% of patients will experience local recurrence and 10% will have distant metastasis, in contrast to high-grade tumors in which 33% will recur locally, and 46% will give rise to distant metastases. 1,2 Minor salivary gland ACCs tend to have indolent behavior, with local recurrence being uncommon and distant metastasis very rare.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Minor salivary gland ACCs tend to have indolent behavior, with local recurrence being uncommon and distant metastasis very rare. 1 …”

Section: Discussionmentioning

confidence: 99%

Relapsed Acinic Cell Carcinoma of the Parotid Gland With Diffuse Distant Metastasis

Khelfa

Mansour

Abdel-Aziz

et al. 2016

Journal of Investigative Medicine High Impact Case Reports

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Acinic cell carcinoma (ACC) is an uncommon salivary gland neoplasm that generally displays an indolent growth pattern. Most cases arise in the major glands, particularly the parotid. However, it can arise from minor salivary glands in the oral cavity and aero-digestive tract. Although ACC is generally a low-grade malignant tumor, poorly differentiated and high-grade transformed variants exhibit a propensity for late recurrence and metastasis. There are no adequate clinical trials that define the optimal approach to patients with metastatic salivary gland tumors due to its rarity. Systemic therapy is reserved for cases where local therapy, such as radiation or metastasectomy, is not appropriate. Nevertheless, there is insufficient data in the literature regarding the chemotherapy of choice for metastatic ACC. In this article, we report a case of metastatic ACC of the right parotid gland that progressed on carboplatin and paclitaxel after partial response followed by doxorubicin and is currently on checkpoint inhibitor treatment.

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Acinic Cell Carcinoma of Minor Salivary Glands: A Clinicopathologic Study of 21 Cases

Cited by 39 publications

References 12 publications

Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands

Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands

Acinic cell carcinoma of the retromolar trigone region: expanding the tumor phenotype in Cowden syndrome?

Relapsed Acinic Cell Carcinoma of the Parotid Gland With Diffuse Distant Metastasis

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