Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

Song, Rundi; Li, Tianliang; Ye, Jiayi; Sun, Fei; Hou, Bo; Saeed, Madiha; Gao, Jing; Wang, Yingjie; Zhu, Qiwen; Xu, Zhiai; Yu, Haijun

doi:10.1002/adma.202101155

Cited by 210 publications

(130 citation statements)

References 38 publications

(17 reference statements)

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“…More importantly, based on their intrinsic connections of O 2 and ROS, a combination of PDT and ferroptosis will achieve a synergistic effect to initiate strong immune response. In addition, PDT can activate T lymphocytes to release IFN-γ, which will facilitate the ferroptosis-related lipid peroxidation to further improve the ICD effect 177 - 180 . Therefore, novel nanoplatforms developed by the rational integration of PDT, ferroptosis, and immunotherapy have attracted much attention for cancer treatment 180 .…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…In addition, PDT can activate T lymphocytes to release IFN-γ, which will facilitate the ferroptosis-related lipid peroxidation to further improve the ICD effect 177 - 180 . Therefore, novel nanoplatforms developed by the rational integration of PDT, ferroptosis, and immunotherapy have attracted much attention for cancer treatment 180 . Finally, in-depth exploration of the relationship between PDT and cancer immunotherapy is still needed, and more advanced nanomedicines will boost the effectiveness and safety of combinational cancer immunotherapy 181 .…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Ji¹,

Wei²,

Yang³

2022

Theranostics

228

117

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Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to immunotherapy because of a powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity of tumors. Photodynamic therapy (PDT) can not only directly kill tumor cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature and complex TME significantly reduce the efficiency of PDT. Recently, smart nanomedicine-based strategies could subtly modulate the pharmacokinetics of therapeutic compounds and the TME to optimize both PDT and immunotherapy, resulting in an improved antitumor effect. Here, the emerging nanomedicines for PDT-driven cancer immunotherapy are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, and subcellular targeted nanoparticles (NPs). Moreover, we highlight the synergistic nanotherapeutics used to amplify immune responses combined with immunotherapy against tumors. Lastly, the challenges and future expectations in the field of PDT-driven cancer immunotherapy are discussed.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Ji¹,

Wei²,

Yang³

2022

Theranostics

228

117

View full text Add to dashboard Cite

show abstract

“…Song et al developed acidity-activatable dynamic nanoparticles encapsulating RSL-3 to target GPX4, unveiling a strategy for ferroptosis-inducing tumor specific delivery. This nanoparticle approach acts to potentiate immunotherapy by recruiting tumor-infiltrating T lymphocytes for interferon gamma (IFNγ) secretion [57]. Hou et al demonstrated that metformin induces TNBC cell ferroptosis via an upregulation of miR-324-3p, by which GPX4 expression is inhibited by targeting its 3 UTR [58].…”

Section: Inducing Ferroptosis By Inhibiting Antioxidant Defensementioning

confidence: 99%

The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future

Lin

Chang

et al. 2021

Cancers

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Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC.

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“… Lung metastasis of 4T1 breast tumors The combination of nanoparticle-induced ferroptosis and blockade of programmed death ligand 1 efficiently inhibits growth of B16-F10 melanoma tumor and lung metastasis of 4T1 breast tumors, suggesting the promising potential of ferroptosis induction for promoting cancer immunotherapy. [ 90 ] Zero-valent-iron nanoparticle (ZVI-NP) ZVI-NP caused mitochondria dysfunction, intracellular oxidative stress, and lipid peroxidation, leading to ferroptotic death of lung cancer cells. Degradation of NRF2 by GSK3/β-TrCP through AMPK/mTOR activation was enhanced in such cancer-specific ferroptosis.…”

Section: The Role Of Ferroptosis In Lung Cancermentioning

confidence: 99%

Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

Chen¹,

Zhang²,

Jiao³

et al. 2021

JIR

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Lung cancer is characterized by high morbidity and mortality rates, and its occurrence is associated with many types of cell death. As a new form of regulated cell death, ferroptosis is an iron- dependent pattern of cell death and characterized by lethal accumulation of lipid-based reactive oxygen species (ROS), which is different from apoptosis, necrosis and autophagy at both the morphological and biochemical levels. It plays an important role in the development of lung cancer and induction of ferroptosis in lung cancer cells has become a new strategy for anti- lung cancer treatment. However, a few reviews summarized ferroptosis and its role in lung cancer has not been elucidated, and the precise mechanism of ferroptosis modeling lung cancer has not yet been revealed till date. Herein, we review the latest literature on the process of ferroptosis regarding lung cancer, including basic molecular or biology mechanistic studies both in vivo and in vitro, as well as human studies with a more translational or clinical approach. This review provides a practical, concise and updated outline on the mechanisms and therapeutic strategies in lung cancer with ferroptosis alterations. Looking ahead, further studies are required to uncover the possible modulatory relationship between ferroptosis and lung cancer.

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Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

Cited by 210 publications

References 38 publications

Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future

Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

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