1993
DOI: 10.1021/bi00091a037
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Abstract: Recombinant human brain-derived neurotrophic factor in acid undergoes a slow loss of tertiary structure as monitored by both near-UV circular dichroism and fluorescence, and appears to retain some secondary structure, as monitored by far-UV circular dichroism and Fourier transform infrared spectroscopy. This loss of tertiary structure parallels a decrease in the weight average molecular weight, from dimer to monomer, when examined using light scattering. Increasing the temperature accelerates this slow reactio… Show more

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