volume 32, issue 44, P11878-11885 1993
DOI: 10.1021/bi00095a017
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Yuji Goto, Yoshihisa Hagihara, Daizo Hamada, Masaru Hoshino, Ichiro Nishii

Abstract: Whereas the salt-dependent conformational transition of acid-denatured horse ferricytochrome c at pH 2 is approximated by a two-state mechanism from the acid-unfolded state to the molten globule state [Kataoka, M., Hagihara, Y., Mihara, K., & Goto, Y. (1993) J. Mol. Biol. 229, 591-596], the corresponding transition in D2O has been proposed to involve a noncompact, alpha-helical intermediate state (the pre-molten globule state) [Jeng, M.-F., & Englander, S. W. (1991) J. Mol. Biol. 221, 1045-1061]. To examine th…

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