PLoS ONE volume 9, issue 5, Pe98291 2014 DOI: 10.1371/journal.pone.0098291 View full text
Yu-ming M. Huang, Chia-en A. Chang

Abstract: The regulation of a series of cellular events requires specific protein–protein interactions, which are usually mediated by modular domains to precisely select a particular sequence from diverse partners. However, most signaling domains can bind to more than one peptide sequence. How do proteins create promiscuity from precision? Moreover, these complex interactions typically occur at the interface of a well-defined secondary structure, α helix and β sheet. However, the molecular recognition primarily controll…

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